• Publications
  • Invited Speaker
  • Invited Lecture
  • 日本語総説
  • 国内シンポジウム、学会発表、講演会
  • 280. Furukawa J., Hanamatsu H., Yokota I., Hirayama M., Ando T., Kobayashi H., Ohnishi S., Miura N., Okada K., Sakai S., Yuyama K., Igarashi Y., Ito. M., Shinohara Y., Sakamoto N.
    A comprehensive glycomic approach reveals novel low-molecular weight blood group-specific glycans in serum and cerebrospinal fluid.
    J. Proteome Res. 2021;20(5):2812-2822.

    279. Mikami D., Sakai S., Nishimukai M., Yuyama K., Mukai K., Igarashi Y.
    Structure-dependent absorption of atypical sphingoid long-chain bases from digestive tract into lymph.
    Lipids in Health and Disease 2021;20(1):24.

    278. Yaguchi K., Sato K., Yoshizawa K., Mikami D., Yuyama K., Igarashi Y., Banhegy G., Margittai E., Uehara R.
    Mevalonate pathway-mediated ER homeostasis is required for haploid stability in human somatic cells.
    Cell Structure and Function 2020;doi:10.1247/csf.20055.

    277. Sugimoto M., Hamada T., Wakabayashi M., Yoshioka T., Kato H., Konishi H., Nagai R., Suzuki M., Numata Y., Igarashi Y., Yukioka H.
    Sphingomyelin synthase 2 loss suppresses steatosis but exacerbates fibrosis in the liver of mice fed with choline-deficient, L-amino acid-defined, high-fat diet.
    Biochem Biophys Res Comm. 2020;533(4):1269-1275.

    276. Yuyama K., Sun H., Mikami D., Mukai K., Igarashi Y.
    Lysosomal-associated transmembrane protein 4B regulates ceramide-induced exosome release.
    FASEB. J. 2020;34(12):16022-16033.

    275. Eguchi K., Mikami D., Sun H., Tsumita T., Takahashi K., Mukai K., Yuyama K., Igarashi Y.
    Blood-brain barrier permeability analysis of plant ceramides.
    Plos One 2020;15(11):e0241640.

    274. Sunami H., Shimizu Y., Denda J., Yokota I., Kishimoto H., Igarashi Y.
    A 3D Microfabricated Scaffold System for Unidirectional Cell Migration.
    Advanced Biosystems 2020;4(10):e2000113.

    273. Usuki S., Yasutake Y., Tamura N., Tamura T., Tanji K., Saitoh T., MuraiY., Mikami D., Yuyama K., Monde K., Mukai K., Igarashi Y.
    Nrp1 is Activated by Konjac Ceramide Binding-Induced Structural Rigidification of the a1a2 Domain.
    Cells 2020;9(2):517. doi:10.3390/cells9020517.

    272. Yuyama K., Takahashi K., Usuki S., Mikami D., Sun H., Hanamatsu H., Furukawa J., Mukai K., Igarashi Y.
    Plant sphingolipids promote extracellular vesicle release and alleviate amyloid-β pathologies in a mouse model of Alzheimer’s disease.
    Sci.Rep. 2019;9(1):16827.

    271. Othman MA., Yuyama K., Murai Y., Igarashi Y., Mikami D., Sivasothy Y., Awang K., Monde K.
    Malabaricone C as natural sphingomyelin synthase inhibitor against diet-induced obesity and its lipid metabolism in mice.
    ACS Medicinal Chemistry Letters 2019;10(8):1154-1158.

    270. Usuki S., Tamura N., Tamura T., Tanji K., Mikami D., Mukai K., Igarashi Y.
    Neurite outgrowth and morphological changes induced by 8-trans unsaturation of sphingadienine in kCer molecular species.
    Int. J. Mol. Sci. 2019;20(9).

    269. Mikami D., Sakai S., Yuyama K., Igarashi Y.
    Isolation of sphingoid bases from starfish Asterias amurensis glucosylceramides and their effects on sphingolipid production in cultured keratinocytes.
    J. Oleo Sci. 2019;68(5):427-441.

    268. Usuki S., Tamura N., Tamura T., Higashiyama S., Tanji K., Mitsutake S., Inoue A., Aoki J., Mukai K., Igarashi Y.
    Konjac Ceramide (kCer) Regulates Keratinocyte Migration by Sema3A-like Repulsion Mechanism.
    Biochemistry and Biophysics Reports 2019;17:132-138.

    267. Swamy M., Murai Y., Ohno Y., Jojima K., Kihara A., Mitsutake S., Igarashi Y., Yu J., Yao M., Suga Y., Anetai M., Monde K.
    Structure-inspired design of a sphingolipid mimic sphingosine-1-phosphate receptor agonist from a naturally occurring sphingomyelin synthase inhibitor.
    ChemComm. 2018;54(90):12758-12761.

    266. Hanamatsu H., Mitsutake S., Sakai S., Okazaki T., Watanabe K., Igarashi Y., Yuyama K.
    Multiple roles of Sms2 in white and brown adipose tissues from diet-induced obese mice.
    J. Metabolic Syndrome 2018;7(2).

    265. Esaki S., Nagasawa T., Tanaka H., Tominaga A., Mikami D., Usuki S., Hamajima H., Hanamatsu H., Sakai S., Hama Y., Igarashi Y., Kitagaki H., Mitsutake S.
    The fungal 9-methylsphingadienine is a novel ligand for both PPARg and GPR120.
    J. Food Biochem. 2018;42(5):e12624.

    264. Zama K., Mitsutake S., Okazaki T., Igarashi Y.
    Sphingomyelin in microdomains of the plasma membrane regulates amino acid-stimulated mTOR signal activation.
    Cell Biology International 2018;42(7):823-831.

    263. Nakamichi H., Nagasawa T., Hama Y., Higashiyama S., Igarashi Y., Mitsutake S.
    Phytosphingosine is a novel activator of GPR120.
    J. Biochem. 2018;164(1):27-32.

    262. Usuki S., Tamura N., Tamura T., Mukai K., Igarashi Y.
    Characterization of Konjac Ceramide (kCer) Binding to Sema3A Receptor Nrp1.
    J. Oleo Science. 2018;67(1):87-94.

    261. Usuki S., Tamura N., Yuyama K., Tamura T., Mukai K., Igarashi Y.
    Konjac Ceramide (kCer) Regulates NGF-Induced Neurite Outgrowth via the Sema3A Signaling Pathway.
    J. Oleo Science. 2018;67(1):77-86.

    260. Sunami H., Shimizu Y., Denda J., Yokota I., Yoshizawa T., Uechi Y., Nakasone H., Igarashi Y., Kishimoto H., Matsushita M.
    Modulation of surface stiffness and cell patterning on polymer films using micropatterns.
    Journal of Biomedical Materials Research: Part B - Applied Biomaterials 2018;106(3):976-985.

    259. Sunami H., Shimizu Y., Yokota I., Igarashi Y., Kishimoto H., Matsushita M.
    Live cell migration on a Microfabricated Silicon Wafer.
    Hyomen kagaku 2017;38(9):473-478.

    258. Yuyama K., Igarashi Y.
    Exosomes as carriers of Alzheimer’s amyloid-β.
    Frontiers in Neuroscience 2017;11:229.

    257. Sanaki T., Kasai-Yamamoto E., Yoshioka T., Sakai S., Yuyama K., Fujiwara T., Numata Y., Igarashi Y.
    Direct involvement of arachidonic acid in the development of ear edema via TRPV3.
    J Oleo Science. 2017;66(6):591-599.

    256. Sakamoto H., Yoshida T., Sanaki T., Shigaki S., Morita H., Oyama M., Mitsui M., Tanaka Y., Nakano T., Mitsutake S., Igarashi Y., Takemoto H.
    Possible roles of long-chain sphingomyelines and sphingomyelin synthase 2 in mouse macrophage inflammatory response.
    Biochem. Biophys. Res. Commun. 2017;482(2):202-207.

    255. Wakabayashi M., Yoshioka T., Higashino K., Numata Y., Igarashi Y., Kihara A.
    Decreases in 15-lipoxygenase metabolites in Olmsted syndrome model rats.
    J Dermatol Sci. 2017;85(3):186-196.

    254. Saito S., Murai Y., Usuki S., Yoshida M., Hammam M.A.S., MItsutake S., Yuyama K., Igarashi Y., Monde K.
    Synthesis of Nontoxic Fluorous Sphingolipids as Molecular Probes of Exogenous Metabolic Studies for Rapid Enrichment by Fluorous Solid Phase Extraction.
    Eur. J. Org. Chem. 2017;6:1045-1051.

    253. Sekiguchi H., Suzuki T., Sakai S., Takahashi K., Hayashida S., Sutoh K., Usumi K., Katsumata Y., Igarashi Y.
    A Study of Safety and Skin Improvment Effect of Beverage Containing Extracted Glucosylceramide form Tamogitake (Pleurotus cornucopiae var. citrinopileatus).
    Trace Nutrients Research 2016;33:21-30.

    252. Taniguchi M., Tasaki T., Ninomiya H., Ueda Y., Kuremoto K., Mitsutake S., Igarashi Y., Okazaki T., Takegami T.
    Sphingomyelin generated by sphingomyelin synthase 1 is involved in attachment and infection with Japanese encephalitis virus.
    Scientific Reports 2016;6:37829.

    251. Sugimoto M., Shimizu Y., Zhao S., Ukon N., Nishijima K., Wakabayashi M., Yoshioka T., Higashino K., Numata Y., Okuda T., Tamaki N., Hanamatsu H., Igarashi Y., Kuge Y.
    Characterization of the role of sphingomyelin synthase 2 in glucose metabolism in whole-body and peripheral tissues in mice.
    BBA - Molecular and Cell Biology of Lipids 2016;1861(8 Pt A):688-702.

    250. Mikami D., Sakai S., Sasaki S., Igarashi Y.
    Effects of Asterias amurensis-derived sphingoid bases on the de novo ceramide synthesis in cultured normal human epidermal keratinocytes.
    Journal of Oleo Science 2016;65(8):671-680.

    249. Sugimoto M., Wakabayashi M., Shimizu Y., Yoshioka T., Higashino K., Numata Y., Okuda T., Zhao S., Sakai S., Igarashi Y., Kuge Y.
    Imaging Mass Spectrometry Reveals Acyl-Chain- and Region-Specific Sphingolipid Metabolism in the Kidneys of Sphingomyelin Synthase 2-Deficient Mice.
    PLoS One 2016;11(3):e0152191.

    248. Yuyama K., Igarashi Y.
    Physiological and Pathological Roles of Exosomes in the Nervous System.
    Biomolecular Concepts 2016;7(1):53-68.

    247. Gowda BS., Usuki S., Mostafa H., Murai Y., Igarashi Y., Monde K.
    Highly Efficient Preparation of Sphingoid Bases from Glucosylceramides by Chemoenzymatic Method.
    J. LIpid Res. 2016;57(2):325-331.

    246. Usuki S., Tamura N., Sakai S., Tamura T., Mukai K., Igarashi Y.
    Chemoenzymatically prepared konjac ceramide inhibits NGF-induced neurite outgrowth by a semaphorin 3A-like action.
    Biochemistry and Biophysics Reports 2016;5:160-167.

    245. Suzuki M., Cao K., Kato S., Komizu Y., Mizutani N., Tanaka K., Arima C., Tai MC., Yanagisawa K., Togawa N., Shiraishi T., Usami N., Taniguchi T., Fukui T., Yokoi K., Wakahara K., Hasegawa Y., Mizutani Y., Igarashi Y., Inokuchi J., Iwaki S., Fujii S., Satou A., Matsumoto Y., Ueoka R., Tamiya-Koizumi K., Murate T., Nakamura M., Kyogashima M., Takahashi T.
    Targeting CERS6-dependent Metastasis-prone Phenotype in Lung Cancer Cells.
    J. Clin. Invest. 2016;126(1):254-265.

    244. Furukawa J., Sakai S., Yokota I., Okada K., Hanamatsu H., Kobayashi T., Yoshida Y., Higashino K., Tamura T., Igarashi Y., Shinohara Y.
    Quantitative glycosphingolipid-glycome analysis of human whole serum based on an endoglycoceramidase digestion and glycoblotting method.
    J. Lipid Res. 2015;56(12):2399-2407.

    243. Sugimoto M., Shimizu Y., Yoshioka T., Wakabayashi M., Tanaka Y., Higashino K., Numata Y., Sakai S., Kihara A., Igarashi Y., Kuge Y.
    Histological analyses by matrix-assisted laser desorption/ionization-imaging mass spectrometry reveal differential localization of sphingomyelin molecular species regulated by particular ceramide synthase in mouse brains.
    BBA - Molecular and Cell Biology of Lipids 2015;1851(12):1554-1565.

    242. Yamagami K., Yamamoto T., Sakai S., Mioka T., Sano T., Igarashi Y., Tanaka K.
    Inositol depletion restores vesicle transport in yeast phospholipid flippase mutant.
    PloS One 2015;10(3):e0120108.

    241. Yuyama K., Sun H., Usuki S., Sakai S., Hanamatsu H., Mioka T, Kimura N., Okada M., Tahara H., Furukawa J., Fujitani N., Shinohara Y., Igarashi Y.
    A potential function for neuronal exosomes: sequestering intracerebral amyloid-β peptide.
    FEBS Letters 2015;589(1):84-88.

    240. Hanamatsu H., Ohnishi S., Sakai S., Yuyama K., Mitsutake S., Takeda H., Hashino S., Igarashi Y.
    Altered levels of serum sphingomyelin and ceramide containing distinct acyl chains in young obese adults.
    Nutrition and Diabetes 2014;4:e141.

    239. Yuyama K., Sun H., Sakai S., Mitsutake S., Okada M., Tahara H., Furukawa JI., Fujitani N., Shinohara Y., Igarashi Y.
    Decreased Amyloid-β Pathologies by Intracerebral Loading of Glycosphingolipid-enriched Exosomes in Alzheimer Model Mice.
    J. Biol. Chem. 2014;289(35):24488-24498.

    238. Sunami H., Yokota I., Igarashi Y.
    Estimation of the angles migrating cells turn on three-dimensional micro-patterned scaffolds by live cell imaging with an inverted microscope.
    e-Journal of Surface Science and Nanotechnology 2014;12:289-298.

    237. Yuyama K., Mitsutake S., Igarashi Y.
    Pathological roles of ceramide and its metabolites in metabolic syndrome and Alzheimer's disease.
    BBA - Molecular and Cell Biology of Lipids 2014;1841(5):793-798.

    236. Sunami H., Yokota I., Igarashi Y.
    Influence of the pattern size of micropatterned scaffolds on cell morphology, proliferation,migration and F-actin expression.
    Biomater. Sci. First published online 2013 Nov 28.

    235. Mizutani Y., Sun H., Ohno Y., Sassa T., Wakashima T., Obara M., Yuyama K., Kihara A., Igarashi Y.
    Cooperative Synthesis of Ultra Long-chain Fatty Acid and Ceramide during Keratinocyte Differentiation.
    Plos one 2013;8(6):e67317.

    234. Mitsutake S., Igarashi Y.
    Sphingolipids in lipid microdomain and obesity.
    Vitamin and Hormones 2013;91 Obesity:271-284.

    233. Hara-Yokoyama M., Terasawa K., Ichinose S., Watanabe A., Katarzyna A., Podyma-Inoue KA., Akiyoshi K., Igarashi Y., Yanagishita M.
    Sphingosine kinase 2 inhibitor SG-12 induces apoptosis via phosphorylation by sphingosine kinase 2.
    Bioorganic & Medicinal Chemistry Letter 2013;23(7):2220-2224.

    232. Murakami I., Mitsutake S., Kobayashi N., Matsuda J., Suzuki A., Shigyo T., Igarashi Y.
    Oral administration of phytosphingosine improves high-fat diet-induced glucose intolerance.
    Bioscience, Biotechnology, and Biochemistry 2013;77(1):194-197.

    231. Taniguchi M., Kitatani K., Kondo T., Nishimura M.H., Asano S., Hayashi A., Mitsutake S., Igarashi Y., Umehara H., Hiroyuki T., Kigawa J., Okazaki T.
    Regulation of autophagy and its associated cell death by sphingolipid rheostat: reciprocal role of ceramide and sphingosine-1-phosphate in the mTOR pathway.
    Journal of Biological Chemistry 2012;287(47):39898-39910.

    230. Zama K., Mitsutake S., Watanabe K., Okazaki T., Igarashi Y.
    A sensitive cell-based method to screen for selective inhibitors of SMS1 or SMS2 using HPLC and a fluorescent substrate.
    Chemistry and Physics of Lipids 2012;165(7):760-768.

    229. Shirakura Y., Kikuchi K., Matsumura K., Mukai K., Mitsutake S., Igarashi Y.
    4,8-Sphingadienine and 4-hydroxy-8-sphingenine activate ceramide production in the skin.
    Lipids in Health and Disease 2012;11(1):108.

    228. Asano S., Kitatani K., Taniguchi M., Hashimoto M., Zama K., Mitsutake S., Igarashi Y., Takeya M., Hayash A., Umehara H., Okazaki T.
    Regulation of Cell Migration by Sphingomyelin Synthases: Sphingomyelin in Lipid Rafts Decreases Responsiveness to Signaling by the CXCL12/CXCR4 Pathway.
    Molecular and Cell Biology 2012;32(16):3242-3252.

    227. Mitsutake S., Date T., Yokota H., Sugiura M., Kohama T., Igarashi Y.
    Ceramide kinase deficiency improves diet-induced obesity and insulin resistance.
    FEBS Letters 2012;586(9):1300-1305.

    226. Fujii Y., Ueda Y., Ohtake H., Ono N., Takayama T., Nakazawa K., Igarashi Y., Goitsuka R.
    Blocking S1P interaction with S1P1 receptor by a novel competitive S1P1-selective antagonist inhibits angiogenesis.
    Biochem Biophys Res Commun. 2012;419(4):754-760.

    225. Yuyama K., Sun H., Mitsutake S., Igarashi Y.
    Sphingolipid-modulated exosome secretion promotes the clearance of amyloid-beta by microglia.
    J. Biol. Chem. 2012;287(14):10977-10989.

    224. Fujii Y., Ohtake H., Ono N., Hara T., Sakurai T., Takahashi S., Takayama T., Fukasawa Y., Shiozawa F., Tsukahara N., Hirayama T., Igarashi Y., Goitsuka R.
    Lymphopenia induced by a novel selective S1P1 antagonist structurally unrelated to S1P.
    BBA, molecular and cell biology of lipid 2012;1821(4):600-606.

    223. Fujii Y., Hirayama T., Ohtake H., Ono N., Inoue T., Sakurai T., Takayama T., Matsumoto K., Tsukahara N., Hidano S., Harima N., Nakazawa K., Igarashi Y., Goitsuka R.
    Amelioration of Collangen-Induced Arthritis by a Novel S1P1 Antagonist with Immunomodulatory Activities.
    J Immunol. 2012;188(1)206-215.

    222. Fujitani N., Takegawa Y., Ishibashi Y., Araki K., Furukawa JI., Mitsutake S., Igarashi Y., Ito M., Shinohara Y.
    Qualitative and Quantitative Cellular Glycomics of Glycosphingolipids Based on Rhodococcal EGCase -Assisted Glycan Cleavage, Glycoblotting-Assisted Sample Preparation and MALDI-TOF/TOF MS Analysis.
    J. Biol. Chem. 2011;286(48):41669-41679.

    221. Shakor AB., Taniguchi M., Kitatani K., Hashimoto M., Asano S., Hayashi A., Nomura K., Bielawski J., Bielawska A., Watanabe K., Kobayashi T., Igarashi Y., Umehara H., Takeya H., Okazaki T.
    SMS1-generatedsphingomyelin plays an important role in transferrin trafficking and cell proliferation
    J. Biol. Chem. 2011;286(41):36053-36062.

    220. Murakami I., Wakasa Y., Yamashita S., Kurihara T., Zama K., Kobayashi N., Mizutani Y., Mitsutake S., Shigyo T., Igarashi Y.
    Phytoceramide and sphingoid bases derived from brewer's yeast Saccharomyces pastorianus activate peroxisome proliferator-activated receptors.
    Lipids in Health and Disease 2011;10:150.

    219. Mitsutake S., Zama K., Yokota H., Yoshida T., Tanaka M., Mitsui M., Ikawa M., Okabe M., Tanaka Y., Yamashita T., Takemoto H., Okazaki T., Watanabe K., Igarashi Y.
    Dynamics modification of sphingomyelin in lipid microdomains control development of obesity, fatty liver, and type 2 diabetes.
    J. Biol. Chem. 2011;286(32):28544-28555.

    218. Okuda A., Naganuma T., Ohno Y., Abe K., Yamagata M., Igarashi Y., Kihara A.
    Hetero-oligomeric interactions of an ELOVL4 mutant protein: implications in the molecular mechanism of Stargardt-3 macular dystrophy.
    Molecular Vision 2010;16:2438-2445.

    217. Fujiwara K., Kitatani K., Yazama H., Umehara H., Kikuchi M., Igarashi Y., Kitano H., Okazaki T.
    Inhibitory effects of dietary glucosylceramides on squamous cell carcinoma of the head and neck in NOD/SCID mice. Int J Clin Oncol 2011;16(2):133-140.

    216. Ohno Y., Suto S., Yamanakaa M., Mizutani Y., Mitsutake S., Igarashi Y., Sassa T., Kihara A.
    ELOVL1 production of C24 acyl-CoAs is linked to C24 sphingolipid synthesis
    Proc. Natl. Acad. Sci. 2010;107(43):18439-18444.

    215. Mitsutake S., Suzuki C., Akiyama M., Tsuji K., Yanagi T., Shimizu H., Igarashi Y.
    ABCA12 dysfunction causes a disorder in glucosylceramide accumulation during keratinocyte differentiation
    J. Dermatol. Sci. 2010;60(2):128-129.

    214. Mitsutake S., Kumada H., Soga M., Hurue Y., Asanuma F., Nagira M., Deguchi M., Date T., Yokose U., Inagaki Y., Sugiura M., Kohama T., Igarashi Y.
    Ceramide kinase is not essential but might act as an Ca2+-sensor for mast cell-activation.
    Prostaglandins & Other Lipid Mediators 2010;93(3-4):109-112.

    213. Nozaki H., Itonori S., Sugita M., Nakamura K., Ohba K., Ohnishi M., Imai K., Igarashi Y., Suzuki A., Kushi Y.
    Invariant Vα14 natural killer T cell activation by edible mushroom acidic glycosphingolipids.
    Biol. Pharm. Bull. 2010:33(4):580-584.

    212. Nishimura H., Akiyama T., Monobe Y., Matsubara K., Igarashi Y., Abe M., Sugihara T., Sadahira Y.
    Expression of Sphingosine-1-phosphate receptor 1 in mantle cell lymphoma.
    Modern Pathology 2010;23(3):439-449.

    211. Igarashi Y., Kannagi R.
    Glycosphingolipids as mediators of phenotypic changes associated with development and cancer progression.
    J. Biochem. 2010;147(1):3-8.

    210. Ishikawa J., Takada S., Hashizume K., Takagi Y., Hotta M., Masukawa Y., Kitahara T., Mizutani Y., Igarashi Y.
    Dietary glucosylceramide is absorbed into the lymph and increases levels of epidermal sphingolipids.
    J Dermatol Sci 2009;56(3):216-218.

    209. Ohno Y., Ito A., Ogata R., Hiraga Y., Igarashi Y., Kihara A.
    Palmitoylation of the sphingosine 1-phosphate receptor S1P1 is involved in its signaling functions and internalization.
    Genes to Cells 2009;14(8):911-923.

    208. Mizutani Y., Mitsutake S., kihara A., Igarashi Y.
    Ceramide biosynthesis in keratinocyte and its role in skin function.
    Biochimie. 2009;91(6):784-790.

    207. Tsuji K., Satoh S., Mitsutake S,, Murakami I., Jeong-Ju Park., Qian Li., Young-Tae Chang., Sung-Kee Chung., Igarashi Y.
    Evaluation of synthetic sphingolipid analogs as ligands for peroxisome proliferator-activated receptors.
    Bioorganic & Medicinal Chemistry Letters. 2009;19(6):1643-1646.

    206. Akiyama T., Hamazaki S., Monobe Y., Nishimura H., Irei I., Igarashi Y., Sadahira Y.
    Sphingosine-1-phosphate receptor 1 is a useful adjunct for distinguishing vascular neoplasms from morphological mimics
    Virchows Archiv. 2009;454(2):217-222.

    205. Sato T., Nihei Y., Nagafuku M., Tagami S., Chin R., Kawamura M., Miyazaki S., Suzuki M., Sugahara S-i., Takahashi Y., Saito A., Igarashi Y., Inokuchi JI.
    Circulating levels of ganglioside GM3 in metabolic syndrome: Apilotstudy.
    Obesity Research & Clinical Practice. 2008;2(4):231-238.

    204. Sato T., Nagafuku M., Shimizu K., Taira T., Igarashi Y., Inokuchi J-I.
    Physiological levels of insulin and IGF-1 synergistically enhance the differentiation of mesenteric adipocytes.
    Cell Biol Int. 2008;32(11):1397-1404.

    203. Hara-Yokoyama M., Terasawa K., Kihara A., Kim J-W., Park S-j., Hirabayashi Y., Igarashi Y., Yanagishita M.
    Sphingosine kinase 2 inhibitor accelerates Fas-mediated cell death progression in A20/2J cells.
    The Open Bioactive Compound J. 2008;1:22-27.

    202. Yamanaka M., Anada Y., Igarashi Y., Kihara A.
    A splicing isoform of LPP1, LPP1a, exhibits high phosphatase activity toward FTY720 phosphate.
    BBRC 2008;375(4):675-679.

    201. Akiyama T., Sadahira Y., Matsubara K., Mori M., Igarashi Y.
    Immunohistochemical detection of sphingosine-1-phosphate receptor 1 in vascular andlymphatic endothelial cells.
    Journal of Molecular Histology. 2008;39(5):527-533.

    200. Jin YX., Shi LH., Yoo HS., Lee YM., Kihara A., Igarashi Y., So HY., Yim YH.
    A sphingosine kinase activity assay using direct infusion electrospray ionization tandem mass spectrometry.
    Anal. Biochem. 2008;380(1):35-40.

    199. Tsuji K., Mitsutake S., Yokose U., Sugiura M., Kohama T., Igarashi Y.
    Role of ceramide kinase in peroxisome proliferator-activated receptor beta-induced cell survival of mouse keratinocytes.
    FEBS J. 2008;275(15):3815-3826.

    198. Ikeda M., Kanao Y., Yamanaka M., Sakuraba H., Mizutani Y., Igarashi Y., Kihara A.
    Characterization of four mammalian 3-hydroxyacyl-CoA dehydratases involved in very long-chain fatty acid synthesis.
    FEBS Lett. 2008;582(16):2435-2440.

    197. Mizutani Y., Kihara A., Chiba H., Tojo H., Igarashi Y.
    2-Hydroxy-ceramide synthesis by ceramide synthase family: enzymatic basis for the preference of FA chain length.
    J. Lipid Res. 2008;49(11):2356-2364.

    196. Kihara A., Igarashi Y.
    Production and release of sphingosine 1-phosphate and the phosphorylated form of the immunomodulator FTY720.
    Biochim Biophys Acta. 2008;1781(9):496-502. Review

    195. Tomiyama T., kaihou S., Ishida M., Nishikawa H., Yamazaki N., Tsuji K., Mitsutake S., Igarashi Y.
    The water retention effects and action for atopic dermatitis-like symptoms of ethyl alcohol extracts ( from Tamogi-take mushroom) on animal model of atopic dermatitis.
    J. Jpn. Soc. Nutr. Food Sci. 2008;61:21-26.

    194. Kohno T., Igarashi Y.
    The attenuation of cell motility observed with high doses of sphingosine 1-phosphate or phosphorylated FTY720 involves RGS2 through its interactions with the receptor S1P1.
    Gene Cell. 2008;13(7):747-757.

    193. Machida T., Hamaya Y., Izumi S., Hamaya Y., Iizuka K., Igarashi Y., Minami M., Levi R., Hirafuji M.
    Sphingosine 1-phosphate Inhibits Nitric Oxide Production induced by Interleukin-1 in Rat Vascular Smooth Muscle Cells.
    Journal of Pharmacology And Experimental Therapeutics. 2008;321(1):200-209.

    192. Kihara A., Sakuraba H., Ikeda M., Denpoh A., Igarashi Y.
    Membrane topology and essential amino acid residues of PHS1, a 3-hydoroxyacyl-CoA Dehydratase involved in very long-chain fatty acid elongation.
    J. Biol. Chem. 2008;283(17):11199-11209.

    191. Ikeda M., Kihara A., Denpoh A., Igarashi Y.
    The Rim101 pathway is involved in Rsb1 expression induced by altered lipid asymmetry.
    Mol. Biol. Cell. 2008;19(5):1922-1931.

    190. Kabayama K., Sato T., Saito K., Loberto N., Prinetti A., Sonnino S., Kinjo M., Igarashi Y., Inokuchi J.
    Dissociation of the insulin receptor and caveolin-1 complex by ganglioside GM3 in the state of insulin resistance.
    Proc Natl Acad Sci U S A. 2007;104(34):13678-13683.

    189. Mitsutake S., Yokose U., Kato M., Matsuoka I., Yoo LM., Kim TJ., Yoo HS., Fujimoto K., Ando Y., Sugiura M., Kohama T., Igarashi Y.
    The generation and behavioral analysis of ceramide kinase-null mice, indicating a function in cerebellar Purkinje cells.
    Biochem Biophys Res Commun. 2007;363(3):519-524.

    188. Date T., Mitsutake S., Igarashi Y.
    Ceramide kinase expression is altered during macrophage-like cell differentiation of the leukemia cell line HL-60.
    In Vitro Cellular & Developmental Biology - Animal. 2007;43(10):321-323.

    187. Iwaki S., Sano T., Takagi T., Osumi M., Kihara A., Igarashi Y.
    Intracellular trafficking pathway of yeast long-chain base kinase Lcb4, from its sythesis to its degradation.
    J. Biol. Chem. 2007;282(39):28485-28492.

    186. Noguchi M., Suzuki T., Kabayama K., Takahashi H., Chiba H., Shiratori M., Abe S., Watanabe A., Satoh M., Hasegawa T., Tagami S., Ishii A., Saito M., Kaneko M., Iseki K., Igarashi Y., Inokuchi J.
    GM3 synthase gene is a novel biomarker for histological classification and drug sensitivity against epidermal growth factor receptor tyrosine kinase inhibitors in non-small cell lung cancer.
    Cancer Science. 2007;98(10):1625-1632. Epub 2007 Aug 16.

    185. Kumada H., Mitsutake M., Igarashi Y.
    Kinetics of the ceramide kinase inhibitor K1, a suppressor of mast cell activation.
    Biosci. Biotech. Biochem. 2007;71(10):2581-2584.

    184. Mitsutake M., Igarashi Y.
    Transbilayer movement of ceramide in the plasma membrane of live cells.
    Biochem Biophys Res Commun. 2007;359(3):622-627.

    183. Kasahara K., Nakayama Y., Kihara A., Matsuda D., Ikeda K., Kuga T., Fukumoto Y., Igarashi Y., Yamaguchi N.
    Rapid trafficking of c-Src, a non-palmitoylated Src-family kinase, between the plasma membrane and late endosomes/lysosomes.
    Exp. Cell Res. 2007;313(12):2651-2666. Epub 2007 May 8.

    182. Anada Y., Igarashi Y., Kihara A.
    The immunomodulator FTY720 is phosphorylated and released from platelets.
    Eur J Pharm. 2007;568(1-3):106-111.

    181. Nodai A., Machida T., Izumi S., Hamaya Y., Kohno T., Igarashi Y., Iizuka K., Minami M., Hirafuji M.
    Sphingosine 1-phosphate induces cyclooxygenase-2 via Ca2+-dependent, but MAPK-independent mechanism in rat vascular smooth muscle cells.
    Life Sci. 2007;80(19):1768-1776. Epub 2007 Feb 20.

    180. Kihara A., Mitsutake S., Mizutani Y., Igarashi Y.
    Metabolism and biological functions of two phosphorylated sphingolipids, sphingosine 1-phosphate and ceramide 1-phosphate.
    Prog. Lipid Res. 2007;46(2):126-144.

    179. Ito K., Anada Y., Tani M., Ikeda M., Sano T., Kihara A., Igarashi Y.
    Lack of sphingosine 1-phosphate (S1P)-degrading enzymes in erythrocytes, a potential major source of plasma S1P in addition to platelets.
    Biochem Biophys Res Commun. 2007;357(1):212-217. Epub 2007 Mar 28.

    178. Uemura S., Feng F., Kume M., Yamada K., Kabayama K., Nishimura S-I., Igarashi Y., Inokuchi J.
    Cell Growth Arrest by Sialic Acid Clusters in Ganglioside GM3 Mimetic Polymers.
    Glycobiology. 2007;17(6):568-577.

    177. Uemura S., Kihara A., Iwaki S., Inokuchi JI., Igarashi Y.
    Regulation of the transport and protein levels of the inositol phosphorylceramide mannosyltransferases Csg1 and Csh1 by the Ca2+-binding protein Csg2.
    J Biol Chem. 2007;282(12):8613-8621.

    176. Tani M., Ito M., Igarashi Y.
    Ceramide/sphingosine/sphingosine 1-phosphate metabolism on the cell surface and in the extracellular space.
    Cell Signal. 2007;19(2):229-237. Epub 2006 Sep 11. Review.

    175. Matsuyuki H., Maeda Y., Yano K., Sugahara K., Chiba K., Kohno T., Igarashi Y.
    Involvement of Sphingosine 1-Phosphate (S1P) Receptor Type 1 and Type 4 in Migratory Response of Mouse T Cells Toward S1P.
    Cell Mol Immunol. 2006;3(6):429-437.

    174. Jin YX, Yoo HS., Kihara A., Choi CH., Oh S., Moon DC., Igarashi Y., Lee YM.
    Sphingosine kinase assay system with fluorescent detection in high performance liquid chromatography.
    Arch Pharm Res. 2006;29(11):1049-1054.

    173. Tsuji K., Mitsutake S., Ishikawa J., Takagi Y., Akiyama M., Shimizu H., Tomiyama T., Igarashi Y.
    Dietary glucosylceramide improves skin barrier function in hairless mice.
    J Dermatol Sci. 2006;44(2):101-107. Epub 2006 Sep 26.

    172. Igarashi Y., Kihara A., Hirabayashi Y.
    The genes in yeast and mammals.
    Sphingolipid Biology. (Springer, Ed. by Hirabayashi Y, Igarashi. Y and Merrill A) 2006;pp 515-517.

    171. Inokuchi J., Kabayama K., Sato T., Igarashi Y.
    A new pathological feature of insulin resistance and type 2 diabetes: involvement of ganglioside GM3 and membrane microdomains.
    Sphingolipid Biology. (Springer, Ed. by Hirabayashi Y, Igarashi. Y and Merrill A) 2006;pp 273-284.

    170. Mitsutake S., Kim TJ., Igarashi Y.
    Ceramide 1-phosphate.
    Sphingolipid Biology. (Springer, Ed. by Hirabayashi Y, Igarashi. Y and Merrill A) 2006;pp 207-218.

    169. Kihara A., Igarashi Y.
    Synthesis, metabolism, and trans-bilayer movement of long-chain base.
    Sphingolipid Biology. (Springer, Ed. by Hirabayashi Y, Igarashi. Y and Merrill A) 2006;pp 95-106.

    168. Yatomi Y., Aoki S., Igarashi Y.
    phingosine1-phosphate-related metabolism in the bllod vessel.
    Sphingolipid Biology. (Springer, Ed. by Hirabayashi Y, Igarashi. Y and Merrill A) 2006;pp 427-439.

    167. Takuwa Y., Sugimoto N., Takuwa N., Igarashi Y.
    Signalling mechanisms for positive and negative regulation of cell motility by sphingosine1-phosphate receptors.
    Sphingolipid Biology. (Springer, Ed. by Hirabayashi Y, Igarashi. Y and Merrill A) 2006;pp 415-426.

    166. Hirabayashi Y., Igarashi Y., Merrill AH.
    phingolipids synthesis, transport and cvellular sibnaling.
    Sphingolipid Biology (Springer, Ed. by Hirabayashi Y, Igarashi. Y and Merrill A) 2006;pp 3-22.

    165. Ikeda M., Kihara A., Igarashi Y.
    Lipid asymmetry of the eukaryotic plasma membrane: functions and related enzymes.
    Biol Pharm Bull. 2006;29(8):1542-1546. Review.

    164. Mizutani Y., Kihara A., Igarashi Y.
    LASS3 is a testis-specific (dihydro)ceramide synthase with relatively broad substrate specificity.
    Biochem. J. 2006;398(3):531-538.

    163. Hiraga Y., Kihara A., Sano T., Igarashi Y.
    Changes in S1P1 and S1P2 expression during embryonal development and primitive endoderm differentiation of F9 cells.
    Biochem Biophys Res Commun. 2006;344(3):852-858. Epub 2006 Apr 19.

    162. Noguchi M., Kabayama K., Uemura S., Kang BW., Saito M., Igarashi Y., Inokuchi JI.
    Endogenously Produced Ganglioside GM3 Endows Etoposide and Doxorubicin Resistance by Up-regulating Bcl-2 Expression in 3LL Lewis Lung Carcinoma Cells.
    Glycobiology. 2006;16(7):641-650. Epub 2006 Mar 29.

    161. Inagaki Y., Mitsutake S., Igarashi Y.
    Identification of a nuclear localization signal in the retinitis pigmentosa-mutated RP26 protein, ceramide kinase-like protein.
    Biochem Biophys Res Commun. 2006;343(3):982-987.

    160. Ohno Y., Kihara A., Sano T., Igarashi Y.
    Intracellular localization and tissue-specific distribution of human and yeast DHHC cysteine-rich domain-containing proteins.
    Biochim Biophys Acta. 2006;1761(4):474-483. Epub 2006 Apr 7.

    159. Akao Y., Banno Y., Nakagawa Y., Hasegawa N., Kim TJ., Murate T., Igarashi Y., Nozawa Y.
    High expression of sphingosine kinase 1 and S1P receptors in chemotherapy-resistant prostate cancer PC3 cells and their camptothecin-induced up-regulation.
    Biochem Biophys Res Commun. 2006;342(4):1284-1290.

    158. Kim TJ., Mitsutake S., Igarashi Y.
    The interaction between the pleckstrin homology domain and phosphatidylinositol 4,5-bisphosphate regulates the plasma membrane targeting and ceramide 1-phosphate levels.
    Biochem Biophys Res Commun. 2006;342(2):611-617.

    157. Kobayashi N., Nishi T., Hirata T., Kihara A., Sano T., Igarashi Y., Yamaguchi A.
    Sphingosine 1-phosphate is released from the cytosol of rat platelets in a carrier-mediated manner.
    J Lipid Res. 2006;47(3):614-621.

    156. Uemura S., Kurose T., Suzuki T., Yoshida S., Ito M., Saito M., Horiuchi M., Inagaki F., Igarashi Y., Inokuchi JI.
    Substitution of the N-glycan function in glycosyltransferases by specific amino acids: ST3Gal-V as a model enzyme.
    Glycobiology. 2006;16(3):258-270.

    155. Kihara A., Anada Y., Igarashi Y.
    Mouse sphingosine kinase isoforms SPHK1a and SPHK1b differ in enzymatic traits including stability, localization, modification, and oligomerization.
    J Biol Chem. 2006;281(7):4532-4539.

    154. Takeda S., Mitsutake S., Tsuji K., Igarashi Y.
    Apoptosis Occurs via the Ceramide Recycling Pathway in Human HaCaT Keratinocytes.
    J Biochem (Tokyo). 2006;139(2):255-262.

    153. Tani M., Kihara A., Igarashi Y.
    Rescue of cell growth by sphingosine in Saccharomyces cerevisiae deficient in sphingolipid biosynthesis with disruption of lipid microdomain formation.
    Biochem J. 2006;394(Pt 1):237-242.

    152. Kim JW., Inagaki Y., Mitsutake S., Maezawa N., Katsumura S., Ryu YW., Park CS., Taniguchi M., Igarashi Y.
    Suppression of mast cell degranulation by a novel ceramide kinase inhibitor, the F-12509A olefin isomer K1.
    Biochim Biophys Acta. 2005;1738(1-3):82-90.

    151. Mitsutake S., Igarashi Y.
    Calmodulin is involved in the Ca2+-dependent activation of ceramide kinase as a calcium-sensor.
    J. Biol. Chem. 2005;280(49):40436-40441.

    150. Sano T., Kihara A., Kurotsu F., Iwaki S., Igarashi Y.
    Regulation of the sphingoid long-chain base kinase Lcb4p by ergosterol and heme: Studies in phytosphingosine-resistant mutants.
    J Biol Chem. 2005;280(44):36674-36682.

    149. Tani M., Igarashi Y., Ito M.
    Involvement of neutral ceramidase in ceramide metabolism at the plasma membrane and in extracellular milieu.
    J Biol Chem. 2005;280(44):36592-36600.

    148. Kihara A., Kurotsu F., Sano T., Iwaki S., Igarashi Y.
    Long-chain base kinase Lcb4 is anchored to the membrane through its palmitoylation by Akr1.
    Mol. Cell. Biol. 2005;25(21):9189-9197.

    147. Tani M., Sano T., Ito M., Igarashi Y.
    Mechanisms of sphingosine and sphingosine 1-phosphate generation in human platelets.
    J Lipid Res. 2005;46(11):2458-2467.

    146. Kim TJ., Mitsutake S., Kato M., Igarashi Y.
    The leucine 10 residue in the pleckstrin homology domain of ceramide kinase is crucial for its catalytic activity.
    FEBS Lett. 2005;579(20):4383-4388.

    145. Mizutani Y., Kihara A., Igarashi Y.
    Mammalian longevity assurance homolog LASS6 and its related family members regulate synthesis of specific ceramides.
    Biochem J. 2005;390(Pt 1):263-271.

    144. Sato T., Zakaria AM., Uemura S., Ishii A., Ohno-Iwashita Y., Igarashi Y., Inokuchi JI.
    Role for upregulated ganglioside biosynthesis and association of Src family kinases with microdomains in retinoic acid-induced differentiation of F9 embryonal carcinoma cells.
    Glycobiology. 2005;15(7):687-699.

    143. Kariya Y., Kihara A., Ikeda M., Kikuchi F., Nakamura S., Hashimoto S., Choi CH., Lee YM., Igarashi Y.
    The sphingosine kinase/sphingosine 1-phosphate (S1P) lyase pathway, and not S1P, stimulates mitogenesis.
    Genes Cells. 2005;10(6):605-615.

    142. Yabu T., Tomimoto H., Taguchi Y., Yamaoka S., Igarashi Y., Okazaki T.
    Thalidomide-induced anti-angiogenic action is mediated by ceramide through depletion of VEGF receptors, and antagonized by sphingosine-1-phosphate.

    141. Kim JW., Kim YW., Inagaki Y., Hwang YA., Mitsutake S., Ryu YW., Lee WK., Ha HJ., Park CS., Igarashi Y.
    Synthesis and evaluation of sphingoid analogs as inhibitors of sphingosine kinases.
    Bioorg. Med. Chem. 2005;13(10):3475-3485.

    140. Inagaki Y., Pham TT., Fujiwara Y., Kohno T., Osborne DA., Igarashi Y., Tigyi G., Parrill AL.
    Sphingosine-1-phosphate analog recognition and selectivity at S1P4 within the endothelial differentiation gene family of receptors.
    Biochem J. 2005;389(Pt 1):187-195.

    139. Ikeda M., Kihara A., Kariya Y., Lee YM., Igarashi Y.
    Sphingolipid-to-glycerophospholipid conversion in SPL-null cells implies the existence of an alternative isozyme.
    Biochem Biophys Res Commun. 2005;329(2):474-479.

    138. Koda M., Murate T., Wang S., Ohguchi K., Ikeda M., Tamiya-Koizumi K,. Igarashi Y., Nozawa Y., Banno Y.
    Sphingosine kinase 1 is involved in dibutyryl cyclic AMP-induced granurocytic differentiation through up-regulation of extracellular signal-regulated kinase, but not p38 MAP kinase, in HL60 cells.
    Biochim Biophys Acta. 2005;1733(2-3):101-110.

    137. Iwaki S., Kihara A., Sano T., Igarashi Y.
    Phosphorylation by Pho85 cyclin-dependent kinase acts as a signal for the down-regulation of the yeast sphingoid long-chain base kinase Lcb4 during the stationary phase.
    J Biol Chem. 2005;280(8):6520-6527.

    136. Yokota S., Taniguchi Y., Kihara A., Mitsutake S., Igarashi Y. (2004)
    Asp177 in C4 domain of mouse sphingosine kinase 1a is important for the sphingosine recognition.
    FEBS Lett. 578:106-110.

    135. Ikeda M., Kihara A., Igarashi Y. (2004)
    Sphingosine-1-phosphate lyase SPL is an endoplasmic reticulum-resident, integral membrane protein with the pyridoxal 5'-phosphate binding domain exposed to the cytosol.
    Biochem. Biophys. Res. Commun. 325: 338-343.

    134. Kabayama K., Sato T., Kitamura F., Uemura S., Kang BW., Igarashi Y., Inokuchi J. (2005)
    TNFalpha-induced insulin resistance in adipocytes as a membrane microdomain disorder: involvement of ganglioside GM3.
    Glycobiology 15: 21-29.

    133. Kihara A., Igarashi Y. (2004)
    FVT-1 is a mammalian 3-ketodihydrosphingosine reductase with an active site that faces the cytosolic side of the endoplasmic reticulum membrane.
    J. Biol. Chem. 279: 49243-49250.

    132. Kihara A., Igarashi Y. (2004)
    Cross talk between sphingolipids and glycerophospholipids in the establishment of plasma membrane asymmetry.
    Mol. Biol. Cell. 15: 4949-4959.

    131. Yatomi Y., Yamamura S., Hisano N., Nakahara K., Igarashi Y., Ozaki Y. (2004)
    Sphingosine 1-phosphate breakdown in platelets.
    J. Biochem. (Tokyo) 136: 495-502.

    130. Kohno T., Igarashi Y. (2004)
    Roles for N-glycosylation in the dynamics of Edg-1/S1P1 in sphingosine 1-phosphate-stimulated cells.
    Glycoconjugate J. 21: 497-501. Review.

    129. Mitsutake S., Kim TJ., Inagaki Y., Kato M., Yamashita T., Igarashi Y. (2004)
    Ceramide kinase is a mediator of calcium-dependent degranulation in mast cells.
    J. Biol. Chem. 279: 17570-17577.

    128. Mizutani Y., Kihara A., Igarashi Y. (2004)
    Identification of the human sphingolipid C4-hydroxylase, hDES2, and its up-regulation during keratinocyte differentiation.
    FEBS Lett. 563: 93-97.

    127. Fukuda Y., Aoyama Y., Wada A., Igarashi Y. (2004)
    Identification of PECAM-1 association with sphingosine kinase 1 and its regulation by agonist-induced phosphorylation.
    Biochim. Biophys. Acta. 1636: 12-21.

    126. Inokuchi J., Kabayama K., Uemura S., Igarashi Y. (2004)
    Glycosphingolipids govern gene expression.
    Glycoconjugate J. 20: 169-178.

    125. Kohno T., Igarashi Y. (2003)
    Truncation of the N-terminal ectodomain has implications in the N-glycosylation and transport to the cell surface of Edg-1/S1P1 receptor.
    J. Biochem. (Tokyo) 134: 667-673.

    124. Fukuda Y., Kihara A., Igarashi Y. (2003)
    Distribution of sphingosine kinase activity in mouse tissues: contribution of SPHK1.
    Biochem. Biophys. Res. Commun. 309: 155-160.

    123. Uemura S., Kihara A., Inokuchi J., Igarashi Y. (2003)
    Csg1p and newly identified Csh1p function in mannosylinositol phosphorylceramide synthesis by interacting with Csg2p.
    J. Biol. Chem. 278: 45049-45055.

    122. Inagaki Y., Li PY., Wada A., Mitsutake S., Igarashi Y. (2003)
    Identification of functional nuclear export sequences in human sphingosine kinase 1.
    Biochem. Biophys. Res. Commun. 311: 168-173.

    121. Kohno T., Matsuyuki H., Inagaki Y., Igarashi Y. (2003)
    Sphingosine 1-phosphate promotes cell migration through the activation of Cdc42 in Edg-6/S1P4-expressing cells.
    Genes Cells. 20: 685-697.

    120. Meacci E., Cencetti F., Donati C., Nuti F., Farnararo M., Kohno T., Igarashi Y., Bruni P. (2003)
    Down-regulation of EDG5/S1P2 during myogenic differentiation results in the specific uncoupling of sphingosine 1-phosphate signalling to phospholipase D.
    Biochim. Biophys. Acta 1633: 133-142.

    119. Kihara A., Sano T., Iwaki S., Igarashi Y. (2003)
    Transmembrane topology of sphingoid long-chain base-1-phosphate phosphatase, Lcb3p.
    Genes Cells. 8: 525-535.

    118. Kihara A., Ikeda M., Kariya Y., Lee EY., Lee YM., Igarashi Y. (2003)
    Sphingosine-1-phosphate lyase is involved in the differentiation of F9 embryonal carcinoma cells to primitive endoderm.
    J. Biol. Chem. 278: 14578-14585.

    117. Hakogi T., Shigenari T., Katsumura S., Sano T., Kohno T., Igarashi Y. (2003)
    Synthesis of fluorescence-labeled sphingosine and sphingosine 1-phosphate; effective tools for sphingosine and sphingosine 1-phosphate behavior.
    Bioorg. Med. Chem. Lett. 13: 661-664.

    116. Yamagishi K., Mishima K., Ohgami Y., Iwasaki K., Jimbo M., Masuda H., Igarashi Y., Inokuchi J., Fujiwara M. (2003)
    A synthetic ceramide analog ameliorates spatial cognition deficit and stimulates biosynthesis of brain gangliosides in rats with cerebral ischemia.
    Eur. J. Pharmacol. 462: 53-60.

    115. Ogawa C., Kihara A., Gokoh M., Igarashi Y. (2003)
    Identification and characterization of a novel human sphingosine-1-phosphate phosphohydrolase, hSPP2.
    J. Biol. Chem. 278: 1268-1272.

    114. Uemura S., Kabayama K., Noguchi M., Igarashi Y., Inokuchi J. (2003)
    Sialylation and sulfation of lactosylceramide distinctly regulate anchorage-independent growth, apoptosis, and gene expression in 3LL Lewis lung carcinoma cells.
    Glycobiology 13: 207-216.

    113. Hirafuji M., Hamaya Y., Matsumoto Y., Machida T., Minami M., Kohno T., Igarashi Y. (2002)
    Modulation of sphingosine 1-phosphate, a new lipid mediator, on nitric oxide production by vascular smooth muscle cells
    Nippon Yakurigaku Zasshi. 120: 70-72. Japanese.

    112. Kihara A., Igarashi Y. (2002)
    Identification and characterization of a Saccharomyces cerevisiae gene, RSB1, involved in sphingoid long-chain base release.
    J. Biol. Chem. 277: 30048-30054.

    111. Chun J., Goetzl EJ., Hla T., Igarashi Y., Lynch KR., Moolenaar W., Pyne S., Tigyi G. (2002)
    International Union of Pharmacology. XXXIV. Lysophospholipid receptor nomenclature.
    Pharmacol. Rev. : 265-269. Review.

    110. Sano T., Baker D., Virag T., Wada A., Yatomi Y., Kobayashi T., Igarashi Y., Tigyi G. (2002)
    Multiple mechanisms linked to platelet activation result in lysophosphatidic acid and sphingosine 1-phosphate generation in blood.
    J. Biol. Chem. 277: 21197-21206.

    109. Kohno T., Wada A., Igarashi Y. (2002)
    N-glycans of sphingosine 1-phosphate receptor Edg-1 regulate ligand-induced receptor internalization.
    FASEB J. 16: 983-992.

    108. Tagami S., Inokuchi JI., Kabayama K., Yoshimura H., Kitamura F., Uemura S., Ogawa C., Ishii A., Saito M., Ohtsuka Y., Sakaue S., Igarashi Y. (2002)
    Ganglioside GM3 participates in the pathological conditions of insulin resistance.
    J. Biol. Chem. 277: 3085-3092.

    107. Kabayama K., Ito N., Honke K., Igarashi Y., Inokuchi J. (2001)
    Suppression of integrin expression and tumorigenicity by sulfation of lactosylceramide in 3LL Lewis lung carcinoma cells.
    J. Biol. Chem. 276: 26777-26783.

    106. Igarashi Y., Yatomi Y., Tigyi G. (2001)
    Production and function of a lipid mediator, sphingosine 1-phosphate in blood, a comparison with lysophosphatidic acid.
    Chem. Phys. Lipid. 108: 20.

    105. Murate T., Banno Y., T-Koizumi K., Watanabe K., Mori N., Wada A., Igarashi Y., Takagi A., Kojima T., Asano H., Akao Y., Yoshida S., Saito H., Nozawa Y. (2001)
    Cell type-specific localization of sphingosine kinase 1a in human tissues.
    J. Histochem. Cytochem. 49: 845-855.

    104. Yatomi Y., Ozaki Y., Ohmori T., Igarashi Y. (2001)
    Sphingosine 1-phosphate: synthesis and release.
    Prostaglandins Other Lipid Mediat. 64: 107-122. Review.

    103. Inokuchi JI., Uemura S., Kabayama K., Igarashi Y. (2000)
    Glycosphingolipid deficiency affects functional microdomain formation in Lewis lung carcinoma cells.
    Glycoconjugate J. 17: 239-245.

    102. Okazaki T., Kitano T., Kondo T., Igarashi Y. (2000)
    Apoptosis by sphingolipids.
    Basic Methodology in Biochemistry (Tokyo Kagaku Dozin). 274-281.

    101. Yatomi Y., Ohmori T., Rile G, Kazama F., Okamoto H., Sano T., Satoh K., Kume S., Tigyi G., Igarashi Y., Ozaki Y. (2000)
    Sphingosine 1-phosphate as a major bioactive lysophospholipid that is released from platelets and interacts with endothelial cells.
    Blood. 96: 3431-3438.

    100. Kohno T., Wada A., Igarashi Y. (2000)
    Aspargine-linked glycosylation of Edg1, a receptor for sphingosine 1-phosphate : Significance in receptor internalization and receptor-coupled signaling.
    Chem. Phys. Lipid. 107: 39.

    99. Jimbo M., Yamagishi K., Yamaki T., Nunomura K., Kabayama K., Igarashi Y., Inokuchi JI. (2000)
    Development of a new inhibitor of glucosylceramide synthase.
    J. Biochem. 127: 485-491.

    98. Motohashi K., Shibata S., Ozaki Y., Yatomi Y., Igarashi Y. (2000)
    Identification of lysophospholipid receptors in human platelets: the relation of two agonists, lysophosphatidic acid and sphingosine 1-phosphate.
    FEBS Lett. 468: 189-193.

    97. Yamamura S., Hakomori S., Wada A., Igarashi Y. (2000)
    Sphingosine-1-phosphate inhibits haptotactic motility by overproduction of focal adhesion sites in B16 melanoma cells through EDG-induced activation of Rho.
    Ann. N. Y. Acad. Sci. 905: 301-307.

    96. Igarashi Y. (1999)
    Physiology and nutrition of glyco and sphingolipids.
    Applied Glyco Science.
    106: 9-15.

    95. Yang L., Yatomi Y., Satoh K., Igarashi Y., Ozaki Y. (1999)
    Sphingosine 1-phosphate formation and intracellular Ca2+ mobilization in human platelets: evaluation with sphingosine kinase inhibitors.
    J. Biochem. 126: 84-89.

    94. Yamamura S., Hakomori S., Wada A., Igarashi Y. (1999)
    Mechanism for inhibition of haptotactic motility by sphingosine 1-phosphate.
    Proc. Jpn Conf Biochem Lipids. 41: 99- 102.

    93. Sweeney EA., Igarashi Y. (1999)
    Increases in ceramide levels in normal human mesangial cells subjected to different cellular stresses result from changes in distinct enzyme activities and can influence cellular responses to other stimuli.
    J. Biochem. 125: 737-745.

    92. Megidish T., Takio K., Titani K., Iwabuchi K., Hamaguchi A., Igarashi Y., Hakomori S. (1999)
    Endogenous substrates of sphingosine-dependent kinases (SDKs) are chaperone proteins: heat shock proteins, glucose-regulated proteins, protein disulfide isomerase, and calreticulin.
    Biochemistry. 38: 3369-3378.

    91. Sato K., Tomura H., Igarashi Y., Ui M., Okajima F. (1999)
    Possible involvement of cell surface receptors in sphingosine 1-phosphate-induced activation of extracellular signal-regulated kinase in C6 glioma cells.
    Mol. Pharmacol.
    55: 126-133.

    90. Hatanaka Y., Fujii J., Fukutomi T., Watanabe T., Che W., Sanada Y., Igarashi Y., Taniguchi N. (1998)
    Reactive oxygen species enhances the induction of inducible nitric oxide synthase by sphingomyelinase in RAW264.7 cells.
    Biochim. Biophys. Acta. 1393: 203-210.

    89. Igarashi Y., Yatomi Y. (1998)
    Sphingosine 1-phosphate is a blood constituent released from activated platelets, possibly playing a variety of physiological and pathophysiological roles.
    Acta Biochim. Pol. 45: 299-309. Review.

    88. Igarashi Y. (1998)
    Sphingosine-1-phosphate as an intercellular signaling molecule.
    Ann. N. Y. Acad. Sci. 845: 19-31.

    87. Sakakura C., Sweeney EA., Shirahama T., Hagiwara A., Yamaguchi T., Takahashi T., Hakomori S., Igarashi Y. (1998)
    Selectivity of sphingosine-induced apoptosis. Lack of activity of DL-erythyro-dihydrosphingosine.
    Biochem. Biophys. Res. Commun. 246: 827-830.

    86. Sweeney EA., Inokuchi J., Igarashi Y. (1998)
    Inhibition of sphingolipid induced apoptosis by caspase inhibitors indicates that sphingosine acts in an earlier part of the apoptotic pathway than ceramide.
    FEBS Lett. 425: 61-65.

    85. Zager RA., Conrad S., Lochhead K., Sweeney EA., Igarashi Y., Burkhart KM. (1998)
    Altered sphingomyelinase and ceramide expression in the setting of ischemic and nephrotoxic acute renal failure.
    Kidney Int. 53: 573-582.

    84. Igarashi Y., Yatomi Y., Kickler TS. (1998)
    Sphingosine-phosphate content in the plasma of platelet concentrates correlates with poor platelet increments after transfusion and with occurrences of transfusion reactions in patients.
    Am. J. Hematol. 57: 261-262.

    83. Hisano N., Yatomi Y., Fujino MA., Igarashi Y., Kume S., Ozaki Y. (1998)
    Quantification of sphingosine derivatives in human platelets: inducible formation of free sphingosine.
    J. Biochem. 123: 263-268.

    82. Igarashi Y., Sadahira Y., Yamamura S., Hakomori S. (1997)
    Inhibition of mouse B16 melanoma cell motility by sphingosine-1-phosphate.
    Adv. Exp. Med. Biol. 400B: 693-698.

    81. Kawa S., Kimura S., Hakomori S., Igarashi Y. (1997)
    Inhibition of chemotactic motility and trans-endothelial migration of human neutrophils by sphingosine 1-phosphate.
    FEBS Lett. 420: 196-200.

    80. Igarashi Y. (1997)
    Functional roles of sphingosine, sphingosine 1-phosphate, and methylsphingosines: in regard to membrane sphingolipid signaling pathways.
    J. Biochem. 122: 1080-1087. Review.

    79. Sato K., Tomura H., Igarashi Y., Ui M., Okajima F. (1997)
    Exogenous sphingosine 1-phosphate induces neurite retraction possibly through a cell surface receptor in PC12 cells.
    Biochem. Biophys. Res. Commun. 240: 329-334.

    78. Yatomi Y., Yamamura S., Ruan F., Kume S., Ozaki Y., Igarashi Y. (1997)
    N,N-dimethylsphingosine 1-phosphate activates human platelets.
    FEBS Lett. 417: 341-344.

    77. Igarashi Y. (1997)
    Physiology of sphingosine 1-phosphate: regulation of cell motility and platelet function
    Seikagaku. 69: 1166-1185. Review. Japanese.

    76. Igarashi Y. (1997)
    Membrane sphingolipid signaling pathways: focusing on functional roles of sphingosine in apoptosis induction.
    Nihonyukagaku kaishi. 46: 1095-1107. Japanese.

    75. Igarashi Y. (1997)
    Regulation of platelet functions by sphingosine derivatives: application for platelet stabilization and preservation and for prevention of platelet transfusion reaction.
    Medicine and Drug J. 33: 2483-2495.

    74. Sakakura C., Sweeney EA., Shirahama T., Igarashi Y., Hakomori S., Tsujimoto H., Imanishi T., Ogaki M., Ohyama T., Yamazaki J., Hagiwara A., Yamaguchi T., Sawai K., Takahashi T. (1997)
    Overexpression of bax sensitizes breast cancer MCF-7 cells to cisplatin and etoposide.
    Surg Today. 27: 676-679.

    73. Yamamura S., Yatomi Y., Ruan F., Sweeney EA., Hakomori S., Igarashi Y. (1997)
    Sphingosine 1-phosphate regulates melanoma cell motility through a receptor-coupled extracellular action and in a pertussis toxin-insensitive manner.
    Biochemistry. 36: 10751-10759.

    72. Zager RA., Iwata M., Conrad DS., Burkhart KM., Igarashi Y. (1997)
    Altered ceramide and sphingosine expression during the induction phase of ischemic acute renal failure.
    Kidney Int. 52: 60-70.

    71. Sakakura C., Sweeney EA., Shirahama T., Solca F., Kohno M., Hakomori S., Fischer EH., Igarashi Y. (1997)
    Inhibition of MAP Kinase by sphingosine and its methylated derivative N,N-dimethylsphingosine; a correlation with induction of apoptosis in solid tumor cells.
    Int. J. Oncol. 11: 31-39.

    70. Shirahama T., Sakakura C., Sweeney EA., Ozawa M., Takemoto M., Nishiyama K., Ohi Y., Igarashi Y. (1997)
    Sphingosine induces apoptosis in androgen-independent human prostatic carcinoma DU-145 cells by suppression of bcl-X(L) gene expression.
    FEBS Lett. 407: 97-100.

    69. Yatomi Y., Igarashi Y., Yang L., Hisano N., Qi R., Asazuma N., Satoh K., Ozaki Y., Kume S. (1997)
    Sphingosine 1-phosphate, a bioactive sphingolipid abundantly stored in platelets, is a normal constituent of human plasma and serum.
    J. Biochem. 121: 969-973.

    68. Yatomi Y., Welch RJ., Igarashi Y. (1997)
    Distribution of sphingosine 1-phosphate, a bioactive sphingolipid, in rat tissues.
    FEBS Lett. 404: 173-174.

    67. Yatomi Y., Ozaki Y., Satoh K., Kume S., Ruan F., Igarashi Y. (1997)
    N,N-dimethylsphingosine phosphorylation in human platelets.
    Biochem. Biophys. Res. Commun. 231: 848-851.

    66. Sakakura C., Sweeney EA., Shirahama T., Igarashi Y., Hakomori S., Tsujimoto H., Imanishi T., Ohgaki M., Yamazaki J., Hagiwara A., Sawai K., Yamaguchi T., Takahashi T. (1997)
    Overexpression of bax enhances the radiation sensitivity in human breast cancer cells.
    Surg. Today. 27: 90-93.

    65. Yatomi Y., Yamamura S., Ruan F., Igarashi Y. (1997)
    Sphingosine 1-phosphate induces platelet activation through an extracellular action and shares a platelet surface receptor with lysophosphatidic acid.
    J. Biol. Chem. 272: 5291-5297.

    64. Shirahama T., Sweeney EA., Sakakura C., Singhal AK., Nishiyama K., Akiyama S., Hakomori S., Igarashi Y. (1997)
    In vitro and in vivo induction of apoptosis by sphingosine and N,N-dimethylsphingosine in human epidermoid carcinoma KB-3-1 and its multidrug-resistant cells.
    Clin. Cancer Res. 3: 257-264.

    63. Kennedy SD., Igarashi Y., Kickler TS. (1997)
    Measurement of in vitro P-selectin expression by flow cytometry.
    Am. J. Clin. Pathol. 107: 99-104.

    62. Yang L., Yatomi Y., Hisano N., Qi R., Asazuma N., Satoh K., Igarashi Y., Ozaki Y., Kume S. (1996)
    Activation of protein-tyrosine kinase Syk in human platelets stimulated with lysophosphatidic acid or sphingosine 1-phosphate.
    Biochem. Biophys. Res. Commun. 229: 440-444.

    61. Sakakura C., Sweeney EA., Shirahama T., Igarashi Y., Hakomori S., Nakatani H., Tsujimoto H., Imanishi T., Ohgaki M., Ohyama T., Yamazaki J., Hagiwara A., Yamaguchi T., Sawai K., Takahashi T. (1996)
    Overexpression of bax sensitizes human breast cancer MCF-7 cells to radiation-induced apoptosis.
    Int. J. Cancer 67: 101-105.

    60. Yatomi Y., Igarashi Y., Hakomori S.
    Effects of exogenous gangliosides on intracellular Ca2+ mobilization and functional responses in human platelets.
    Glycobiology 6: 347-353.

    59. Masamune A., Igarashi Y., Hakomori S. (1996)
    Regulatory role of ceramide in interleukin (IL)-1 beta-induced E-selectin expression in human umbilical vein endothelial cells. Ceramide enhances IL-1 beta action, but is not sufficient for E-selectin expression.
    J. Biol. Chem. 271: 9368-9375.

    58. Sweeney EA., Sakakura C., Shirahama T., Masamune A., Ohta H., Hakomori S., Igarashi Y. (1996)
    Sphingosine and its methylated derivative N,N-dimethylsphingosine (DMS) induce apoptosis in a variety of human cancer cell lines.
    Int. J. Cancer 66: 358-366.

    57. Yamamura S., Sadahira Y., Ruan F., Hakomori S., Igarashi Y. (1996)
    Sphingosine-1-phosphate inhibits actin nucleation and pseudopodium formation to control cell motility of mouse melanoma cells.
    FEBS Lett. 382: 193-197.

    56. Sakakura C., Sweeney EA., Shirahama T., Hakomori S., Igarashi Y. (1996)
    Suppression of bcl-2 gene expression by sphingosine in the apoptosis of human leukemic HL-60 cells during phorbol ester-induced terminal differentiation.
    FEBS Lett. 379: 177-180.

    55. Yatomi Y., Ruan F., Megidish T., Toyokuni T., Hakomori S., Igarashi Y. (1996)
    N,N-dimethylsphingosine inhibition of sphingosine kinase and sphingosine 1-phosphate activity in human platelets.
    Biochemistry 35: 626-633.

    54. Sakakura C., Igarashi Y., Anand JK., Sadozai KK., Hakomori S. (1996)
    Plasmalopsychosine of human brain mimics the effect of nerve growth factor by activating its receptor kinase and mitogen-activated protein kinase in PC12 cells. Induction of neurite outgrowth and prevention of apoptosis.
    J. Biol. Chem. 271: 946-952.

    53. Hakomori S., Igarashi Y. (1996)
    Role of sphingoglycolipids in signal transduction, and their medicinal application for control of tumor progression and inflammatory processes.
    AFMC International Medicinal Chemistry Symposium

    52. Hakomori S., Igarashi Y. (1995)
    Functional role of glycosphingolipids in cell recognition and signaling.
    J .Biochem. (Tokyo) 118: 1091-1103. Review.

    51. Kimura S., Sugita O., Matsuto T., Okada M., Igarashi Y. (1995)
    HPLC application for phosphoinositides analyses of A431 cells and human platelets.
    Acta Medica et Biologica 43: 59-62.

    50. Igarashi Y., Sadahira Y., Yamamura S., Hakomori S. (1995)
    Inhibition of mouse B16 melanoma cell motility by sphingosine-1-phosphate.
    Reports of proceedings of 3rd Int. Conference on Eicosanoids and Other Bioactive Lipids in Cancer, Inflammation and Radiation Injury 2 (Plenum Pub. Co. New York, Eds. by KV Honn et al). pp 693-698.

    49. Megidish T., White T., Takio K., Titani K., Igarashi Y., Hakomori S. (1995)
    The signal modulator protein 14-3-3 is a target of sphingosine- or N,N-dimethylsphingosine-dependent kinase in 3T3(A31) cells.
    Biochem. Biophys. Res. Commun. 216: 739-747.

    48. Yatomi Y., Ruan F., Ohta J., Welch RJ., Hakomori S., Igarashi Y. (1995)
    Quantitative measurement of sphingosine 1-phosphate in biological samples by acylation with radioactive acetic anhydride.
    Anal. Biochem. 230: 315-320.

    47. Ruan F., Yamamura S., Hakomori S., Igarashi Y. (1995)
    Immobilization of sphingosine on controlled pore glass through D-erythro-w-carboxyl sphingosine.
    Tetrahedron Lett. 36: 6615-6618.

    46. Murohara T., Buerke M., Margiotta J., Ruan F., Igarashi Y., Hakomori S., Lefer AM. (1995)
    Myocardial and endothelial protection by N,N,N-trimethylsphingosine in feline myocardial ischemia and reperfusion injury.
    Am. J. Physiol. 269(Heart Circul. Physiol. 38): H504-514.

    45. Hakomori S., Igarashi Y. (1995)
    Glycosphingolipids and sphingolipids closely associated with or causing apoptosis.
    Acta Histochem. Cytochem. 28: 77-82.

    44. Park YS., Ruan F., Hakomori S., Igarashi Y. (1995)
    Cooperative inhibitory effect of liposomal N,N,N-trimethylsphingosine and sphingosine-1- phosphate, co-incorporated in liposomes, on B16 melanoma cell metastasis: cell membrane signaling as a target in cancer therapy IV.
    Int. J. Oncol. 7: 487-494.

    43. Masamune A., Hakomori S., Igarashi Y. (1995)
    N,N,N-trimethylsphingosine inhibits interleukin-1 beta-induced NF-kappa B activation and consequent E-selectin expression in human umbilical vein endothelial cells.
    FEBS Lett. 367: 205-209.

    42. Bornfeldt KE, Graves LM, Raines EW, Igarashi Y., Wayman G., Yamamura S., Yatomi Y., Sidhu JS., Krebs EG., Hakomori S., Roth R. (1995)
    Sphingosine-1-phosphate inhibits PDGF-induced chemotaxis of human arterial smooth muscle cells: spatial and temporal modulation of PDGF chemotactic signal transduction.
    J. Cell Biol. 130: 193-206.

    41. Yatomi Y., Ruan F., Hakomori S., Igarashi Y. (1995)
    Sphingosine-1-phosphate: a platelet-activating sphingolipid released from agonist-stimulated human platelets.
    Blood. 86: 193-202.

    40. Ohta H., Sweeney EA., Masamune A., Yatomi Y., Hakomori S., Igarashi Y. (1995)
    Induction of apoptosis by sphingosine in human leukemic HL-60 cells: a possible endogenous modulator of apoptotic DNA fragmentation occurring during phorbol ester-induced differentiation.
    Cancer Res. 55: 691-697.

    39. Ohta H., Yatomi Y., Sweeney EA., Hakomori S., Igarashi Y. (1994)
    A possible role of sphingosine in induction of apoptosis by tumor necrosis factor-alpha in human neutrophils.
    FEBS Lett. 355: 267-270.

    38. Ohta H., Ruan F., Hakomori S., Igarashi Y. (1994)
    Quantification of free sphingosine in cultured cells by acylation with radioactive acetic anhydride.
    Anal. Biochem.
    222: 489-494.

    37. Park YS., Hakomori S., Kawa S., Ruan F., Igarashi Y. (1994)
    Liposomal N,N,N-trimethylsphingosine (TMS) as an inhibitor of B16 melanoma cell growth and metastasis with reduced toxicity and enhanced drug efficacy compared to free TMS: cell membrane signaling as a target in cancer therapy III.
    Cancer Res. 54: 2213-2217.

    36. Sadahira Y., Zheng M., Ruan F., Hakomori S., Igarashi Y. (1994)
    Sphingosine-1-phosphate inhibits extracellular matrix protein-induced haptotactic motility but not adhesion of B16 mouse melanoma cells.
    FEBS Lett. 340: 99-103.

    35. Mazurek N, Megidish T., Hakomori S., Igarashi Y. (1994)
    Regulatory effect of phorbol esters on sphingosine kinase in BALB/C 3T3 fibroblasts (variant A31): demonstration of cell type-specific response--a preliminary note.
    Biochem. Biophys. Res. Commun. 198:1-9.

    34. Zhou Q., Hakomori S., Kitamura K., Igarashi Y. (1994)
    GM3 directly inhibits tyrosine phosphorylation and de-N-acetyl-GM3 directly enhances serine phosphorylation of epidermal growth factor receptor, independently of receptor-receptor interaction.
    J. Biol. Chem. 269: 1959-1965.

    33. Igarashi Y.(1993)
    A review on cell growth regulation by glycosphingolipids (review in Japanese).
    in "Glycotechnology and related drug development" pp.48-56 (Yakugyojihou-Sha)

    32. Hakomori S., Igarashi Y. (1993)
    Gangliosides and glycosphingolipids as modulators of cell growth, adhesion, and transmembrane signaling.
    Adv. Lipid Res. 25:147-162. Review.

    31. Abdel-Ghany M., Osusky M., Igarashi Y., Hakomori S., Shalloway D., Racker R. (1992)
    Substrate-specific modulation of Src-mediated phosphorylation of Ras and caseins by sphingosines and other substrate modulators.
    Biophys. Biochim. Acta. 113: 349-355.

    30. Kimura S., Kawa S., Ruan F., Nisar M., Sadahira Y., Hakomori S., Igarashi Y. (1992)
    Effect of sphingosine and its N-methyl derivatives on oxidative burst, phagokinetic activity, and trans-endothelial migration of human neutrophils.
    Biochem. Pharmacol. 44: 1585-1595.

    29. Ruan F., Sadahira Y., Hakomori S., Igarashi Y. (1992)
    Chemical synthesis of D-erythro-sphingosine-1-phosphate, and its inhibitory effect on cell motility.
    BioMed. Chem. Lett. 2: 973-978.

    28. Sadahira Y., Ruan F., Hakomori S., Igarashi Y. (1992)
    Sphingosine 1-phosphate, a specific endogenous signaling molecule controlling cell motility and tumor cell invasiveness.
    Proc. Natl. Acad. Sci. USA. 89: 9686-9690.

    27. Nudelman ED., Levery SB., Igarashi Y., Hakomori S. (1992)
    Plasmalopsychosine, a novel plasmal (fatty aldehyde) conjugate of psychosine with cyclic acetal linkage. Isolation and characterization from human brain white matter.
    J. Biol. Chem. 267: 11007-11016.

    26. Handa K., Igarashi Y., Nisar M., Hakomori S. (1991)
    Downregulation of GMP-140 (CD62 or PADGEM) expression on platelets by N,N-dimethyl and N,N,N-trimethyl derivatives of sphingosine.
    Biochemistry 30: 11682-11686.

    25. Okoshi H., Hakomori S., Nisar M., Zhou QH., Kimura S., Tashiro K., Igarashi Y. (1991)
    Cell membrane signaling as target in cancer therapy. II: Inhibitory effect of N,N,N-trimethylsphingosine on metastatic potential of murine B16 melanoma cell line through blocking of tumor cell-dependent platelet aggregation.
    Cancer Res. 51: 6019-6024.

    24. Igarashi Y. (1991)
    Glycosphingolipid and cell growth.
    Gendai Kagaku (Chemistry Today) 248: 22-27.

    23. Endo K., Igarashi Y., Nisar M., Zhou QH., Hakomori S. (1991)
    Cell membrane signaling as target in cancer therapy: inhibitory effect of N,N-dimethyl and N,N,N-trimethyl sphingosine derivatives on in vitro and in vivo growth of human tumor cells in nude mice.
    Cancer Res. 51: 1613-1618.

    22. Felding-Habermann B, Igarashi Y., Fenderson BA., Park LS., Radin NS., Inokuchi J., Strassmann G., Handa K., Hakomori S. (1990)
    A ceramide analogue inhibits T cell proliferative response through inhibition of glycosphingolipid synthesis and enhancement of N,N-dimethylsphingosine synthesis.
    Biochemistry 29: 6314-6322.

    21. Hakomori S., Igarashi Y., Nojiri H., Bremer E., Hanai N., Nores GA. (1990)
    Bioactive gangliosides modulating transmembrane signaling.
    Tropic factors and the nervous system (Horrocks LA et al., eds.) Raven Press, New York, pp135-158.

    20. Igarashi Y., Kitamura K., Toyokuni T., Dean B., Fenderson B., Ogawass T., Hakomori S. (1990)
    A specific enhancing effect of N,N-dimethylsphingosine on epidermal growth factor receptor autophosphorylation. Demonstration of its endogenous occurrence (and the virtual absence of unsubstituted sphingosine) in human epidermoid carcinoma A431 cells.
    J. Biol. Chem. 265: 5385-5389.

    19. Igarashi Y., Kitamura K., Zhou QH., Hakomori S. (1990)
    A role of lyso-phosphatidylcholine in GM3-dependent inhibition of epidermal growth factor receptor autophosphorylation in A431 plasma membranes.
    Biochem. Biophys. Res. Commun. 172: 77-84.

    18. Igarashi Y.(1990)
    Possible roles of sphingosine and N,N-dimethylsphingosine as modulators in membrane signal transduction systems.
    Trends Glycosci. Glycotechnol. 2:319-332.

    17. Igarashi Y., Hakomori S. (1989)
    Enzymatic synthesis of N,N-dimethyl-sphingosine: demonstration of the sphingosine: N-methyltransferase in mouse brain.
    Biochem. Biophys. Res. Commun. 164: 1411-1416.

    16. Igarashi Y., Hakomori S., Toyokuni T., Dean B., Fujita S., Sugimoto M., Ogawa T., el-Ghendy K., Racker E. (1989)
    Effect of chemically well-defined sphingosine and its N-methyl derivatives on protein kinase C and src kinase activities.
    Biochemistry 28: 6796-6800.

    15. Igarashi Y., Nojiri H., Hanai N., Hakomori S. (1989)
    Gangliosides that modulate membrane protein function.
    Methods Enzymol. 179: 521-541.

    14. Igarashi Y., Chambaz EM. (1987)
    A novel inositol glycophospholipid (IGPL) and the serum dependence of its metabolism in bovine adrenocortical cells.
    Biochem. Biophys. Res. Commun. 145: 249-256.

    13. Igarashi Y., Chambaz EM. (1987)
    The metabolic turnover of a novel inositol glycophospholipid (IGPL) in bovine adrenocortical cells is strikingly activated by specific hormones and growth factors.
    Eur. Symp. Hormone and Cell Regul. 12: 251-253.

    12. Igarashi Y., Kimura T. (1986)
    Adrenic acid content in rat adrenal mitochondrial PE and its relation to ACTH-mediated regulation of cholesterol side chain cleavage reaction.
    J. Biol. Chem. 261:14118-14124.

    11. Igarashi Y., Kimura T. (1986)
    Importance of the unsaturated fatty acyl group of phospholipids in their stimulatory role on rat adrenal mitochondrial steroidogenesis.
    Biochemistry. 25: 6461-6466.

    10. Igarashi Y., Kimura T. (1984)
    Adrenocorticotropic hormone-mediated changes in rat adrenal mitochondrial phospholipids.
    J. Biol. Chem. 259: 10745-10753.

    9. Igarashi Y., Kondo Y. (1982)
    Regulation of adenylate cyclase in thyroid membrane by arachidonate and its peroxides.
    Proc. Jpn. Lipid Biochem. 24: 157-160.

    8. Igarashi Y., Kondo Y. (1981)
    Transient increase in prostaglandin production as an acute response of thyroid isolated follicles to thyrotropin.
    Biochem. Biophys. Res. Commun. 99: 1045-1050.

    7. Igarashi Y., Kondo Y. (1981)
    Degradation of phosphatidylinositol and accumulation of diacylglycerol and prostaglandin E in response to TSH.
    Proc. Jpn. Lipid Biochem. 23: 283-286.

    6. Igarashi Y., Kondo Y. (1981)
    TSH-dependent phosphatidylinositol metabolism in the thyroid: A possible role of the "phosphoinositide effect".
    Gunma Symp. Endocrinol. 18: 45-54.

    5. Igarashi Y., Kondo Y. (1980)
    Acute effect of thyrotropin on phosphatidylinositol degradation and transient accumulation of diacylglycerol in isolated thyroid follicles.
    Biochem. Biophys. Res. Commun. 97: 759-765.

    4. Igarashi Y., Kondo Y. (1980)
    Demonstration and characterization of partial glyceride specific lipases in pig thyroid plasma membranes.
    Biochem. Biophys. Res. Commun. 97: 766-771.

    3. Igarashi Y., Yaoi Y. (1975)
    Growth-enhancing protein obtained from cell surface of cultured fibroblasts.
    Nature. 254: 248-250.

    2. Igarashi Y. (1974).
    Carpet protein and cell growth.
    Chemistry and Biology
    12: 7667-7669

    1. Igarashi Y., Sakai H. (1971).
    Study of microtuble protein from sea urchin egg mitotic apparatus.
    Jap. J. Develop. Biol.
    25: 86-87.