I. 原著論文リスト

52. Usuki S., Yasutake Y., Tamura N., Tamura T., Tanji K., Saitoh T., MuraiY., Mikami D., Yuyama K., Monde K., Mukai K., Igarashi Y.
Nrp1 is Activated by Konjac Ceramide Binding-Induced Structural Rigidification of the a1a2 Domain.
Cells  2020 9(2):517; https://doi.org/10.3390/cells9020517.

51. Yuyama K., Takahashi K., Usuki S., Mikami D., Sun H., Hanamatsu H., Furukawa J., Mukai K., Igarashi Y.
Plant sphingolipids promote extracellular vesicle release and alleviate amyloid-β pathologies in a mouse model of Alzheimer’s disease.
Sci.Rep.  2019 9(1):16827.

50. Usuki S., Tamura N., Tamura T., Tanji K., Mikami D., Mukai K., Igarashi Y.
Neurite outgrowth and morphological changes induced by 8-trans unsaturation of sphingadienine in kCer molecular species.
Int J Mol Sci  2019 20(9).

49. Usuki S., Tamura N., Tamura T., Higashiyama S., Tanji K., Mitsutake S., Inoue A., Aoki J., Mukai K., Igarashi Y.
Konjac Ceramide (kCer) Regulates Keratinocyte Migration by Sema3A-like Repulsion Mechanism.
Biochem Biophys Rep  2019 17:132-138.

48. Esaki S., Nagasawa T., Tanaka H., Tominaga A., Mikami D., Usuki S., Hamajima H., Hanamatsu H., Sakai S., Hama Y., Igarashi Y., Kitagaki H., Mitsutake S.
The fungal 9-methylsphingadienine is a novel ligand for both PPARg and GPR120.
J Food Biochem  2018 42(5):e12624.

47. Usuki S., Tamura N., Yuyama K., Tamura T., Mukai K., Igarashi Y.
Konjac Ceramide (kCer) Regulates NGF-Induced Neurite Outgrowth via the Sema3A Signaling Pathway.
J Oleo Science  2018 67(1):77-86.

46. Usuki S., Tamura N., Tamura T., Mukai K., Igarashi Y.
Characterization of Konjac Ceramide (kCer) Binding to Sema3A Receptor Nrp1.
J Oleo Science  2018 67(1):87-94.

45. Saito S., Murai Y., Usuki S., Yoshida M., Hammam M.A.S., MItsutake S., Yuyama K., Igarashi Y., Monde K.
Synthesis of Nontoxic Fluorous Sphingolipids as Molecular Probes of Exogenous Metabolic Studies for Rapid Enrichment by Fluorous Solid Phase Extraction.
Eur J Org Chem  2017 6:1045-1051.

44. Li D., Usuki S., Quarles B., Rivner MH., Ariga T., Yu RK.
Anti-sulfoglucuronosyl paragloboside antibody: A potential serological marker of amyotrophic lateral sclerosis.
ASN Neuro  2016 Sep-Oct; 8(5).1-8.

43. Gowda BS., Usuki S., Mostafa H., Murai Y., Igarashi Y., Monde K.
Highly Efficient Preparation of Sphingoid Bases from Glucosylceramides by Chemoenzymatic Method.
J LIpid Res  2016 57:325-331.

42. Usuki S., Tamura N., Sakai S., Tamura T., Mukai K., Igarashi Y.
Chemoenzymatically prepared konjac ceramide inhibits NGF-induced neurite outgrowth by a semaphorin 3A-like action.
Biochem Biophys Rep  2016 5:160-167.

41. Yu RK., Usuki S., Itokazu Y., Wu HC.
Novel GM1 ganglioside-like peptide mimics prevent the association of cholera toxin to human intestinal epithelial cells in vitro.
Glycobiology  2016 26:63-73.

40. Yuyama K., Sun H., Usuki S., Sakai S., Hanamatsu H., Mioka T., Kimura N., Okada M., Tahara H., Furukawa J., Fujitani N., Shinohara Y., Igarashi Y.
A potential function for neuronal exosomes: sequestering intracerebral amyloid-β peptide.
FEBS Letters  2015 589:84-88.

39. Usuki S., O'Brien D., Rivner MH., Yu RK.
A new approach to ELISA-based anti-glycolipid antibody evaluation of highly adhesive serum samples.
J Immunol Method  2014 408:52-63.

38. Yu RK., Usuki S.
Human antiglycosphingolipids antibodies in Guillain-Barre syndrome.
Autoantibodies 3rd edition  2014 581-692 edited by Shoenfeld Y, Meroni PL, Elsevier B.V.Gershwin ME.

37. Usuki S.
Prospective role of β-cell-specific IGF-1 for oxidative stress in the pathogenesis of diabetic neuropathy.
Journal of Diabetes & Metabolism  2012 S5-009.

36. Yu RK., Usuki S., Ariga T.
Anti-glycolipid antibodies in Guillain-Barre syndrome and related neuropathies: Therapeutic strategies for disease treatment.
Anticarbohydrate Antibodies: Molecular Basis to Clinical Application (Kosma P and Muller-Loennies (eds)  2012 14:327-359.

35. Usuki S., Kamitani T., Matsuo Y., Yu RK.
Pathobiochemical Effect of Acylated Steryl-β-Glucoside on Aggregation and Cytotoxicity of α-Synuclein.
Neurochem Res  2012 37:1261-1266.

34. Usuki S., Tsai Y., Morikawa K., Nonaka S., Okuhara Y., Kise M., Yu RK.
IGF-1 induction by acylated steryl β-glucosides found in a pre-germinated brown rice diet reduces oxidative stress in streptozotocin induced diabetes.
PLoSONE  2011 6:12 e28693.

33. Yu RK., Ariga T., Usuki S., Kaida K.
Pathological roles of ganglioside mimicry in Guillain-Barre syndrome and related neuropathies.
Adv Exp Med Biol  2011 705:349-365.

32. Usuki S., Taguchi K., Gu Y-H., Thompson SA., Yu RK.
Development of a Novel Therapy for Lipo-oligosaccharide-induced Experimental Neuritis: Use of Peptide Glycomimics.
J Neurochem  2010 113:351-362.

31. Usuki S., Taguchi K., Thompson SA., Chapman PB., Yu RK.
Novel anti-idiotype antibody therapy for lipopolysaccharide-induced experimental autoimmune neuritis: Use relevant to Guillain-Barre Syndrome.
J Neurosci Res  2010 88:1651-1663.

30. Nakatani Y., Murata M., Shibata K., Nagaoka T., Utsunomiya I., Usuki S., Miyatake T., Hoshi K., Taguchi K.
IgM anti-GQ1b monoclonal antibody inhibits voltage-dependent calcium current in cerebellar granule cells.
Exp Neurol  2009 219:74-80.

29. Usuki S., Nakatani Y., Taguchi K., Fujita T., Tanabe S., Utsunomiya I., Gu Y., Cawthraw SA., Newell DG., Pajaniappan M., Thompson SA., Ariga T., Yu RK.
Topology and patch-clamp analysis of the sodium channel in relationship to the anti-lipid A antibody in campylobacteriosis.
J Neurosci Res  2008 86:3359-3374.

28. Usuki S., Ariga T., Dasguputa S., Kasama T., Morikawa K., Nonaka S., Okuhara Y., Kise M., Yu RK.
Structural analysis of novel acylated steryl glucoside (ASGs) in pre-germinated brown rice bran.
J Lipid Res  2008 49:2188-2196.

27. Ariga T., Suetake K., Nakane M., Kubota M., Usuki S., Kawashima I., Yu RK.
Glycosphingolipid antigens in neural tumor cell lines and anti-glycosphingolipid antibodies in sera of patients with neural tumors.
Neurosignals  2008 16:226-234.

26. Usuki S., Ito Y., Morikawa K., Kise M., Ariga T., Rivner M., Yu RK.
Effect of pre-germinated brown rice intake on diabetic neuropathy in homocysteine-thiolactonase activity in streptszotocin-induced diabetic rat.
Nutrition & Metabolism  2007 4:25:1-11.

25. Usuki S., Pajaniappan M., Thompson SA., Yu RK.
Chemical validation of molecular mimicry: The Interaction of cholera toxin with campylobacter lipooligosaccharides.
Glycoconjugate J  2007 24:167-180.

24. Yu RK., Usuki S., Ariga T.
Ganglioside molecular mimicry and its pathological roles in Guillain-Barre syndrome and related diseases.
Infect Immun  2006 74:6517-6527.

23. Usuki S., Taguchi K., Cawthraw SA., Shibata K., Ariga T., Newell DG., Yu RK.
Human and chicken antibodies to gangliosides following infection by campylobacter jejuni.
Exp Neurol  2006 200:50-55.

22. Usuki S., Thompson SA., Rivner MH., Taguchi K., Shibata K., Ariga T., Yu RK.
Molecular mimicry: Sensitization of Lewis rats with campylobacter jejuni lipopolysaccharides induces formation of antibody toward GD3 ganglioside.
J Neurosci Res  2006 83:274-284.

21. Usuki S, Sanchez J, Ariga T, Utsunomiya I, Taguchi K, Rivner MH, Yu RK.
AIDP and CIDP having specific antibodies to the carbohydrate epitope (-NeuAcα2-8NeuAcα2-3Galβ1 4Glc-) of gangliosides.
J Neurol Sci  2005 232:37-44.

20. Vukelic Z., Zamfir AD., Bindila L., Froesch M., Peter-Katalinic J., Usuki S., Yu RK.
Screening and sequencing of complex sialyated and sulfated glycosphigolipid mixtures by negative ion electrospray fourier transform ion cyclotron resonance mass spectrometry.
J Am Soc Mass Spectrum  2005 16:571-580.

19. Taguchi K., Utsunomiya I., Ren J., Yoshida N., Aoyagi H., Nakatani Y., Ariga T., Usuki S., Yu RK., Miyatake T.
Effect of rabbit anti-asialo-GM1(GA1) polyclonal antibodies on neuromuscular transmission and acetylcholine-induced action potentials: neurophysiological and immunohistochemical studies.
Neurochem Res  2004 29:953-960.

18. Usuki S., Kariya Y., Rosner H., Ishihara M., Sakamoto T., Masuda H., Kyogashima M.
Enhancement of neurite outgrowth-promoting activity by heparin derivatives in sodium chlorate-treated explant cultures of rat central neurons.
J Biochem  2003 133:783-790.

17. Usuki S., Ren J., Utsunomiya I., Cashman NR., Inokuchi J., Miyatake T.
GM2 ganglioside regulates the function of ciliary neurotrophic factor in murine immortalized motor neuron-like cell (NSC-34).
Neurochem Res  2001 26:375-382.

16. Usuki S.
Glycolipids and neurological disorder.
The Tisuue Culture Engineering  2000 26:33-36.

15. Usuki S., Cashman NR., Miyatake T.
GM2 promotes ciliary neurotrophic factor-dependent rescue of immoratlized motor neuron-like cell (NSC-34).
Neurochemical Res  1999 24:281-286.

14. Inokuchi J., Mizutani M., Usuki S., Jimbo M., Motizuki H., Muramoto K., Kobayashi K., Kuroda Y., Iwasaki K., Ohgami Y., Fujiwara M.
Synthetic ceramide analog (L-PDMP) up-regulates neuronal functions.
NY Soc Acad Sci  1998 845:219-224.

13. Usuki S.
Toward the understanding of glycolipid GM3 functions: application of metabolic inhibitors.
J Jpn Oil Chem Soc  1997 46:1075-1086.

12. Inokuchi J., Mizutani A., Jimbo M., Usuki S., Yamagishi K., Motizuki H., Muramoto K., Kobayashi K., Kuroda Y.,Iwasaki K., Ohgami Y., Fujiwara M.
Up-regulation of ganglioside biosynthesis, functional Synapse formation and memory retention by a synthetic ceramide analog (L-PDMP).
Biochim Biophys Res Commun  1997 237:595-600.

11. Usuki S., Hamanoue M., Kohsaka S., Inokuchi J.
Induction of ganglioside biosynthesis and neurite-outgrowth of primary cultured neurons by L-threo-1-phenyl-decanoyl-3-morpholino-1-propanol.
J Neurochem  1996 67:1821-1830.

10. Inokuchi J., Usuki S., Jimbo M.
Stimulation of glycosphingolipid biosynthesis by L-threo-1-phenyl-decanoyl- 3-morpholino-1-propanol and its homologs in B16 melanomas.
J Biochem  1995 117:766-773.

9. Usuki S., Maekawa A., Ho-il K., Shumiya S., Nagase S.
High susceptibility of analbuminemic rats to neurogenic tumor induction by transplacental administration of N-ethyl-N-nitrosourea.
J Cancer Res  1992 83:146-152.

8. Usuki S.
Intracellular traffiking of GM3 sialidase.
Ganglioside News  1991 1,4:26-31.

7. Usuki S.
GM3 sialidase to cultured medium.
Seikagaku  1990 9:1158-1162.

6. Usuki S., Sweeley CC.
Studies on the metabolism of GM3 ganglioside in cultured human fibroblasts.
Human Cell  1989 2:15-21.

5. Sweeley CC., Usuki S.
Secretory sialidase activity and GM3 ganglioside.
New Trends in Ganglioside Research: Neurochemical and Neurogenerative Aspects (Ledeen RW., ed.)  1988 14:307-315.

4. Usuki S., Hoops P., Sweeley CC.
Growth control of human foreskin fibroblasts and inhibition of extracellular sialidase activity by 2-deoxy 2,3-dehydro-N- acetylneuraminic acid.
J Biol Chem  1988 263:10595-10599.

3. Usuki S., Sweeley CC.
Consideration of a functional role of an extracellular sialidase secreted by Cultured fibroblasts.
Indian J Biochem  1988 25:102-105.

2. Usuki S., Lyu SC., Sweeley CC.
Sialidase activities of cultured human fibroblasts and the metabolism of GM3 ganglioside.
J. Biol. Chem.  1988 263:6847-6853.

1. Usuki S., Nagai Y.
Specific tritium labeling of glucosyl- and galactosylceramide at the 6-position of the Carbohydrate moiety using CrO3-graphite.
Anal Biochem  1986 152:172-177.

II. 特許リスト

8. Yu RK, Wu Han-Chung, Usuki S.
GM1-like peptides and uses thereof.
pub #2013/0115170A1 in May 9 2013.

7. Yu RK, Usuki S.
Ganglioside epitopes for treating Guillain-Barre syndrome.
pub #US2011/0131669A1 in May 20 2013.

6. 奥原康英、喜瀬光男、臼杵靖剛、ロバートケーユー、伊藤幸彦、渡辺浩幸、川村真美

5. 臼杵靖剛、ロバートケーユー、森川桂子、喜瀬光男

4. 臼杵靖剛、ロバートケーユー、伊藤幸彦、森川桂子、喜瀬光男

3. 臼杵 靖剛、瀬山 暁子、苅谷 豊

2. 臼杵靖剛、刈谷豊

1. 井ノ口仁一、臼杵靖剛