KYpub

46. 江口晃一、向井克之、湯山耕平、栗本成敬、田中藍子、勝山(鏡)豊代、西平順、門出健次、五十嵐靖之.
こんにゃく由来グルコシドセラミド摂取による脳内アミロイドβ蓄積に対する抑制効果の探索的試験ープラセボ対照ランダム化二重盲検並行群間比較試験ー
薬理と治療 2021.

45. Furukawa J., Hanamatsu H., Yokota I., Hirayama M., Ando T., Kobayashi H., Ohnishi S., Miura N., Okada K., Sakai S., Yuyama K., Igarashi Y., Ito. M., Shinohara Y., Sakamoto N.
A comprehensive glycomic approach reveals novel low-molecular weight blood group-specific glycans in serum and cerebrospinal fluid.
J. Proteome Res. 2021 20(5):2812-2822.

44. Mikami D., Sakai S., Nishimukai M., Yuyama K., Mukai K., Igarashi Y.
Structure-dependent absorption of atypical sphingoid long-chain bases from digestive tract into lymph.
Lipids in Health and Disease 2021 20(1):24.

43. Yaguchi K., Sato K., Yoshizawa K., Mikami D., Yuyama K., Igarashi Y., Banhegy G., Margittai E., Uehara R.
Mevalonate pathway-mediated ER homeostasis is required for haploid stability in human somatic cells.
Cell Structure and Function 2020 doi:10.1247/csf.20055.

42. Eguchi K., Mikami D., Sun H., Tsumita T., Takahashi K., Mukai K., Yuyama K., Igarashi Y.
Blood-brain barrier permeability analysis of plant ceramides.
Plos One 2020 15(11):e0241640.

41. Yuyama K., Sun H., MikamiD., Mukai K., Igarashi Y.
Lysosomal-associated transmembrane protein 4B regulates ceramide-induced exosome release.
FASEB. J. 2020 34(12):16022-16033.

40. Akiyama H., Ide M., Nagatsuka Y., Sayano T., Nakanishi E., Uemura N., Yuyama K., Yamaguchi Y., Kamiguchi H., Takahashi R., Aerts JMFG., Greimel P., Hirabayashi Y.
Glucocerebrosidases catalyze a transgalactosylation reaction that yields a newly identified brain sterol metabolite, galactosylated cholesterol.
J. Biol.Chem. 2020 295(16):5257-5277. doi:10.1074/jbc.RA119.012502.

39. Usuki S., Yasutake Y., Tamura N., Tamura T., Tanji K., Saitoh T., MuraiY., Mikami D., Yuyama K., Monde K., Mukai K., Igarashi Y.
Nrp1 is Activated by Konjac Ceramide Binding-Induced Structural Rigidification of the a1a2 Domain
Cells 2020 9(2):517 https://doi.org/10.3390/cells9020517.

38. Yuyama K., Takahashi K., Usuki S., Mikami D., Sun H., Hanamatsu H., Furukawa J., Mukai K., Igarashi Y.
Plant sphingolipids promote extracellular vesicle release and alleviate amyloid-β pathologies in a mouse model of Alzheimer’s disease.
Sci.Rep. 2019 9(1):16827.

37. Othman MA., Yuyama K., Murai Y., Igarashi Y., Mikami D., Sivasothy Y., Awang K., Monde K.
Malabaricone C as natural sphingomyelin synthase inhibitor against diet-induced obesity and its lipid metabolism in mice.
ACS Medicinal Chemistry Letters 2019 10(8): 1154-1158.

36. Mikami D., Sakai S., Yuyama K., Igarashi Y.
Isolation of sphingoid bases from starfish Asterias amurensis glucosylceramides and their effects on sphingolipid production in cultured keratinocytes.
J. Oleo Sci. 2019 68(5): 427-441.

35. Ohara M., Ohnishi S., Hosono H., Yamamoto K., Yuyama Y., Nakamura H., Qingjie F., Maehara O., Suda G., Sakamoto N.
Extracellular vesicles from amnion-derived mesenchymal stem cells ameliorate hepatic inflammation and fibrosis in rats.
J Stem Cell International 2018 3212643. doi:10.1155/2018/3212643. eCollection 2018.

34. Hanamatsu H., Mitsutake S., Sakai S., Okazaki T., Watanabe K., Igarashi Y., Yuyama K.
Multiple roles of Sms2 in white and brown adipose tissues from diet-induced obese mice.
J. Metabolic Syndrome 2018 7(2).

33. Usuki S., Tamura N., Yuyama K., Tamura T., Mukai K., Igarashi Y.
Konjac Ceramide (kCer) Regulates NGF-Induced Neurite Outgrowth via the Sema3A Signaling Pathway.
J. Oleo Science 2018 67(1): 77-86.

32. Sanaki T,. Kasai-Yamamoto E,. Yoshioka T., Sakai S., Yuyama K,. Fujiwara T,. Numata Y,. Igarashi Y.
Direct involvement of arachidonic acid in the development of ear edema via TRPV3.
J Oleo Science 2017 66(6): 591-599.

31. Saito S., Murai Y., Usuki S., Yoshida M., Hammam M.A.S., Mitsutake S., Yuyama K., Igarashi Y., Monde K.
Synthesis of Nontoxic Fluorous Sphingolipids as Molecular Probes of Exogenous Metabolic Studies for Rapid Enrichment by Fluorous Solid Phase Extraction.
Eur. J. Org. Chem. 2017 6: 1045-1051.

30. Yuyama K., Igarashi Y.
Physiological and Pathological Roles of Exosomes in the Nervous System.
Biomolecular Concepts 2016 7(1): 53-68.

29. Yuyama K., Sun H., Usuki S., Sakai S., Hanamatsu H., Mioka T, Kimura N., Okada M., Tahara H., Furukawa J., Fujitani N., Shinohara Y., Igarashi Y.
A potential function for neuronal exosomes: sequestering intracerebral amyloid-β peptide.
FEBS Letters 2015 589(1): 84-88.

28. Hanamatsu H., Ohnishi S., Sakai S., Yuyama K., Mitsutake S., Takeda H., Hashino S., Igarashi Y.
Altered levels of serum sphingomyelin and ceramide containing distinct acyl chains in young obese adults.
Nutrition and Diabetes 2014 4: e141.

27. Yuyama K., Sun H., Sakai S., Mitsutake S., Okada M., Tahara H., Furukawa JI., Fujitani N., Shinohara Y., Igarashi Y.
Decreased Amyloid-β Pathologies by Intracerebral Loading of Glycosphingolipid-enriched Exosomes in Alzheimer Model Mice.
J. Biol. Chem. 2014 289(35): 24488-24498.

26. Yuyama K., Mitsutake S., Igarashi Y.
Pathological roles of ceramide and its metabolites in metabolic syndrome and Alzheimer's disease.
BBA - Molecular and Cell Biology of Lipids. 2013 1841(5): 793-798.

25. Mizutani Y., Sun H., Ohno Y., Sassa T., Wakashima T., Obara M., Yuyama K., Kihara A., Igarashi Y.
Cooperative Synthesis of Ultra Long-chain Fatty Acid and Ceramide during Keratinocyte Differentiation.
Plos one. 2013 8(6): e67317.

24. Sekino-Suzuki N., Yuyama K., Miki T., Kaneda M., Suzuki H., Yamamoto N., Yamamoto T., Oneyama C., Okada M., Kasahara K.
Involvement of gangliosides in the process of Cbp/PAG phosphorylation by Lyn in developing cerebellar growth cones.
J. Neurochem. 2013 124(4): 514-522.

23. Yuyama K., Sun H., Mitsutake S., Igarashi Y.
Sphingolipid-modulated exosome secretion promotes the clearance of amyloid-beta by microglia.
J. Biol. Chem. 2012 287(14): 10977-10989.

22. Yuyama K., Sekino-Suzuki N., Yamamoto N., Kasahara K.
Ganglioside GD3 monoclonal antibody-induced paxillin tyrosine phosphorylation and filamentous actin assembly in cerebellar growth cones.
J. Neurochem. 2011 116(5): 845-850

21. Yuyama K., Yanagisawa K.
Sphingomyelin accumulation provides a favorable milieu for GM1 ganglioside-induced assembly of amyloid beta-protein.
Neurosci. Lett. 2010 481(3): 168-172.

20. Oikawa N., Yamaguchi H., Ogino K., Taki T., Yuyama K., Yamamoto N., Shin RW., Furukawa K., Yanagisawa K.
Gangliosides determine the amyloid pathology of Alzheimer’s disease.
Neuroreport. 2009 20(12): 1043-1046.

19. Yuyama K., Yanagisawa K.
Late endocytic dysfunction as a putative cause of amyloid fibril formation in Alzheimer’s disease.
J. Neurochem. 2009 109(5): 1250-1260.

18. 湯山耕平、柳澤勝彦
アルツハイマー病におけるエンドサイトーシス障害
Dementia Japan. 2009 23(1): 47-54.

17. 湯山耕平、鈴木直子、笠原浩二
三量体G蛋白質と脂質ラフト
生体の科学. 2009 60(3): 181-186.

16. Yuyama K., Yamamoto N., Yanagisawa K.
Accelerated release of exosome-associated GM1 ganglioside (GM1) by endocytic pathway abnormality: another putative pathway for GM1-induced amyloid fibril formation.
J. Neurochem. 2008 105(1): 217-224.

15. 湯山耕平、鈴木直子、笠原浩二
脂質ラフトと3量体G蛋白質
蛋白質 核酸 酵素. 2008 53(12): 1558-1563.

14. Yuyama K., Sekino-Suzuki N., Sanai Y., Kasahara K.
Translocation of activated heterotrimeric G protein Galpha(o) to ganglioside-enriched detergent-resistant membrane rafts in developing cerebellum.
J. Biol. Chem. 2007 282(36): 26392-26400.

13. Hirai M., Onai T., Koizumi M., Hirai H., Kasahara K., Yuyama K., Suzuki N., Inoue K.
Permeability of water through raft model membrane clarified by time-resolved SANS and SAXS.
J. Appl. Cryst. 2007 40: 159-164.

12. Yuyama K., Sekino-Suzuki N., Kasahara K.
Signal transduction of heterotrimeric G proteins in lipid rafts.
Trends Glycosci.Glycotech. 2007 19, 12-27.

11. Yuyama K., Yamamoto N., Yanagisawa K.
Chloroquine-induced endocytic pathway abnormalities: Cellular model of GM1 ganglioside-induced Abeta fibrillogenesis in Alzheimer's disease.
FEBS Lett. 2006 580(30): 6972-6976.

10. Yamamoto T., Yuyama K., Yamamoto H.
Low concentrations of nitric oxide (NO) induced cell death in PC12 cells through activation of p38 mitogen-activated protein kinase (p38 MAPK) but not via extracellular signal-regulated kinases (ERK1/2) or c-Jun N-terminal protein kinase (JNK).
Neurosci. Lett. 2006 392(3): 170-173.

9. Hirai M., Hirai H., Koizumi M., Kasahara K., Yuyama K., Suzuki N.
Structure of raft-model membrane by using the inverse contrast variation neutron scattering methods.
Physica B: Condensed Matter. 2006 P2: 868-870. 2002.

8. Hirai M., Koizumi M., Hirai H., Hayakawa T., Yuyama K., Suzuki N., Kasahara K.
Structure and dynamics of glycosphingolipid-containing lipid mixtures as raft models of plasma membrane.
Journal of Physics 2006 17: 1-12.

7. 湯山耕平、鈴木直子、佐内豊、笠原浩二
神経細胞接着分子TAG-1の脂質ラフトを介するシグナル伝達
MEMBRANE, 2005 30: 91-93.

6. 鈴木直子、湯山耕平、佐内豊、笠原浩二
神経系における脂質マイクロドメイン
蛋白質 核酸 酵素. 2004 49: 2397-2403.

5. Yuyama K., Sekino-Suzuki N., Sanai Y., Kasahara K.
Lipid rafts in Cellular Signaling and disease.
Trends Glycosci. Glycotech. 2003 15: 139-151.

4. Yuyama K., Yamamoto H., Nakamura K., Nishizaki I., Yamakuni T., Song SY., Sora I., Nagatsu T., Yamamoto T.
Overexpression of V-1 prevents nitric oxide-induced cell death: involvement of enhanced tetrahydrobiopterin biosynthesis.
J. Neurosci. Res. 2003 72(6): 716-725.

3. Yuyama K., Yamamoto H., Nishizaki I., Kato T., Sora I., Yamamoto T.
Caspase-independent cell death by low concentrations of nitric oxide in PC12 cells: involvement of cytochrome C oxidase inhibition and the production of reactive oxygen species in mitochondria.
J. Neurosci. Res. 2003 73(3): 351-363.

2. Yuyama K., Yamamoto H., Nakamura K., Kato T., Sora I., Yamamoto T.
Resistance of PC12 cells against nitric oxide (NO)-induced toxicity in long-term culture: implication of neuronal NO synthase expression.
Neurosci. Lett. 2001 309(3): 169-172.

1. Yamamoto T., Yuyama K., Nakamura K., Kato T., Yamamoto H.
Kinetic characterization of the nitric oxide toxicity for PC12 cells: effect of half-life time of NO release.
Eur. J. Pharmacol. 2000 397(1): 25-33.